FB2024_03 , released June 25, 2024
Allele: Dmel\Su(H)VP16.UAS.Tag:MYC
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General Information
Symbol
Dmel\Su(H)VP16.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0095584
Feature type
allele
Associated gene
Dmel\Su(H)
Associated Insertion(s)
Carried in Construct
P{UAS-Su(H).VP16}
Also Known As
UAS-Su(H)-VP16, UAS-Su(H)VP16, UAS-Su(H).VP16
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kidd et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-Su(H).VP16}
Cytology
Description

Tag:MYC is fused to amino acid 10 of Su(H) coding region, which is then fused at its carboxy-terminus to amino acids 19-105 of Hsim\VP16. Expression of the construct is governed by UASt regulatory sequences.

(Kidd et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Su(H)
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 under the control of Scer\GAL4lz-gal4 leads to significant increases in both the number and size of third instar larval circulating crystal cells, as compared to controls.

      (Miller et al., 2017)

      Stage 13 embryos expressing Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 under the control of Scer\GAL4sim.P3.7 have approximately 16 anterior midline glia (AMG) compared to six in wild type. By stage 16 the number of AMG has reduced to 7, compared to three in wild type.

      (Zhang et al., 2011)

      When Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 is driven by Scer\GAL4how-24B in the mesoderm differentiation of the visceral mesoderm is disrupted.

      (Lawrence et al., 2001)

      When expression is driven by Scer\GAL4dpp.blk1 adult wings show ectopic margin structures, similar to those induced by 'intra' forms of N.

      (Klein et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL415J2/Su(H)VP16.UAS.Tag:MYC is a non-suppressor of abnormal neuroanatomy | recessive phenotype of Nl1N-ts1

      (Kuzina et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Su(H)VP16.UAS.Tag:MYC/Scer\GAL4repo-M1B is a suppressor of pioneer neuron phenotype of Nl1N-ts1

      (Kuzina et al., 2011)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL415J2/Su(H)VP16.UAS.Tag:MYC is a non-suppressor of pioneer neuron phenotype of Nl1N-ts1

      (Kuzina et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 in glia under the control of Scer\GAL4repo-M1B suppresses the Nl1N-ts1 longitudinal pioneer axon phenotype.

      Expression of Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16 in the pioneer neurons under the control of Scer\GAL415J2 fails to suppress the Nl1N-ts1 longitudinal pioneer axon phenotype.

      (Kuzina et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Su(H)Act
      (Carmena et al., 2002)
      Su(H)Scer\UAS.T:Hsap\MYC,T:Hsim\VP16
      Su(H)UAS.T:Myc,T:VP16
      Su(H)VP16.UAS.Tag:MYC
      myc-Su(H)-VP16
      (Kidd et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)