FB2024_03 , released June 25, 2024
Allele: Dmel\NleΔ8
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General Information
Symbol
Dmel\NleΔ8
Species
D. melanogaster
Name
FlyBase ID
FBal0094658
Feature type
allele
Associated gene
Dmel\Nle
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Royet et al., 1998)
Mutagen
P-element activity
(Royet et al., 1998)
Progenitor genotype
Nlek13714
(Royet et al., 1998)
Caused by aberration
Df(2L)NleΔ8
Cytology
Description

Deletion extends away from site of insertion in both directions, removing the 5' portion of the Nle transcription unit (as well as the 5' portion of CG2807).

(Royet et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies heterozygous for NleΔ8 and Nlek13714 are viable, morphologically normal and male sterile. Mutant embryos and clones of mutant cells show no neurogenic phenotypes.

      (Royet et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Nle[+]/NleΔ8 is an enhancer of orbital bristle phenotype of NAx-1

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is an enhancer of dorsocentral bristle phenotype of NAx-1

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is an enhancer of wing vein phenotype of NAx-1

      (Royet et al., 1998)
      Suppressor of
      Statement
      Reference

      Nle[+]/NleΔ8 is a suppressor of wing phenotype of Nnd-1

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is a suppressor of wing vein phenotype of Nnd-1

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is a suppressor of wing phenotype of Nnd-2

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is a suppressor of wing vein phenotype of Nnd-2

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is a suppressor of wing phenotype of Nnd-3

      (Royet et al., 1998)

      Nle[+]/NleΔ8 is a suppressor of wing vein phenotype of Nnd-3

      (Royet et al., 1998)

      NleΔ8 is a suppressor of wing phenotype of dx1

      (Royet et al., 1998)

      NleΔ8 is a suppressor of wing vein phenotype of dx1

      (Royet et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly suppresses wing margin and vein phenotypes of Nnd-1 and Nnd-2 though wing veins are interrupted due to overactivation of N signalling pathway. Dominantly suppresses wing margin and vein phenotypes of Nnd-3, and dx1. Enhances the bristle and wing vein phenotypes of gain of function NAx-1. Reveals sub-threshold effect of dxhs.PB, in effect on wing veins.

      (Royet et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Homozygotes are inviable, probably as a result of a second mutation on the NleΔ8 chromosome.

      (Royet et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      NleΔ8
      Name Synonyms
      Secondary FlyBase IDs
        References (1)