FlyBase Allele Report: Dmel\sktl[Δ5]

General Information

Symbol

Dmel\sktl^Δ5

Species

D. melanogaster

Name

FlyBase ID

FBal0094341

Feature type

allele

Associated gene

Dmel\sktl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

loss of function allele

(Hassan et al., 1998)

Mutagen

Delta2-3 transposase

(Hassan et al., 1998)

Progenitor genotype

sktl^k07505

(Hassan et al., 1998)

Cytology

Description

Deletion removing the P{lacW} and 2.5kb of flanking genomic sequence.

(Hassan et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with sktl^2.3)

(Gervais et al., 2008)

lethal - all die before end of larval stage | recessive

(Hassan et al., 1998)

some die during larval stage | recessive

(Hassan et al., 1998)

Phenotype Manifest In

dorsal appendage (with sktl^2.3), with Scer\GAL4^{VP16.mat.αTub67C}

(Claret et al., 2014)

egg (with sktl^2.3)

(Compagnon et al., 2009)

follicle cell (with sktl^2.3), with Scer\GAL4^{VP16.mat.αTub67C}

(Claret et al., 2014)

wing

(Hassan et al., 1998)

wing & macrochaeta

(Hassan et al., 1998)

Detailed Description

Statement

Reference

The follicle epithelium is multilayered in sktl^2.3/sktl^Δ5 egg chambers in which the germline is rescued by expression of sktl^{Scer\UAS.P\T.T:Avic\GFP} under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}. Dorsal appendages of the resulting egg shells are fused.

(Claret et al., 2014)

60% of eggs laid by sktl^Δ5/sktl^2.3 females are flaccid.

(Compagnon et al., 2009)

Lethality acts in the early first larval instar. Mutants show no obvious defects. Clonal analysis in the wing revealed a requirement for sktl for cell viability and/or growth. The few bristles that are recovered in clones are wavy or bent, indicating cytoskeletal defects.

(Hassan et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sktl⁰⁵⁴⁷⁵

(Prokopenko et al., 2000)

sktl^k07505

(Hassan et al., 1998)

Rescued by

sktl^2.3/sktl^Δ5 is rescued by Scer\GAL4^{VP16.nanos.UTR}/sktl^UASp.cGa

(Gervais et al., 2008)

Comments

Complements insc⁸ and insc²².

(Hassan et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

39673

y¹ w^*; sktl^Δ5/CyO, y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sktl^Δ5

(Jouette et al., 2019, Bothe et al., 2014, Roch et al., 2010, Compagnon et al., 2009, Gervais et al., 2008, Secombe et al., 2007)

sktlΔ5

(Claret et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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