FB2024_03 , released June 25, 2024
Allele: Dmel\ScmM36
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General Information
Symbol
Dmel\ScmM36
Species
D. melanogaster
Name
FlyBase ID
FBal0094004
Feature type
allele
Associated gene
Dmel\Scm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bornemann et al., 1998)
Mutagen
ethyl methanesulfonate
(Bornemann et al., 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: C511Y.

(Bornemann et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,635,501..9,635,501 [-]
Nucleotide change:

G9635501A

Amino acid change:

C511Y | Scm-PA; C511Y | Scm-PB

Reported amino acid change:

C511Y|FBrf0104734

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bornemann et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      ScmM36 is an enhancer of visible | dominant | homeotic phenotype of Pc3

      (Bornemann et al., 1998)
      Suppressor of
      Statement
      Reference

      Scm[+]/ScmM36 is a suppressor of abnormal eye color phenotype of Hsap\MECP2R294X.UAS, Scer\GAL4GMR.PU

      (Cukier et al., 2008)
      Other
      Statement
      Reference

      ScmM36, ph-p409 has partially lethal phenotype

      (Bornemann et al., 1998)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scm[+]/ScmM36 is a suppressor of eye phenotype of Hsap\MECP2UAS.FL, Scer\GAL4GMR.PU

      (Cukier et al., 2008)

      Scm[+]/ScmM36 is a suppressor of eye phenotype of Hsap\MECP2Δ166.UAS, Scer\GAL4GMR.PU

      (Cukier et al., 2008)

      ScmM36 is a suppressor of phenotype of z1

      (Bornemann et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Dominantly enhances the homeotic phenotypes of Pc3/+ adults. ph-p409 males that are also heterozygous for ScmM36 show partial lethality.

      (Bornemann et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Scm4

      (Bornemann et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      M36
      (Cukier et al., 2008)
      ScmM36
      Name Synonyms
      Secondary FlyBase IDs
        References (2)