FB2024_03 , released June 25, 2024
Allele: Mmus\Nkx2-5UAS.cRa
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General Information
Symbol
Mmus\Nkx2-5UAS.cRa
Species
M. musculus
Name
Saccharomyces cerevisiae UAS construct a of Ranganayakulu
FlyBase ID
FBal0093237
Feature type
allele
Associated gene
Mmus\Nkx2-5
Associated Insertion(s)
Carried in Construct
P{UAS-Mmus\Nkx2-5.R}
Transgenic product class
cDNA
(Ranganayakulu et al., 1998)
wild_type
(Ranganayakulu et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ranganayakulu et al., 1998)
wild_type
(Ranganayakulu et al., 1998)
Mutagen
in vitro construct
(Ranganayakulu et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-Mmus\Nkx2-5.R}
Cytology
Description

A Mmus\Nkx2-5 cDNA is expressed under the control of UASt regulatory sequences.

(Ranganayakulu et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Nkx2-5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      embryonic/larval heart & mesoderm, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PB

      (Ranganayakulu et al., 1998)
      Detailed Description
      Statement
      Reference

      In an otherwise wild type background, expression driven by Scer\GAL4twi.PB and Scer\GAL4Mef2.PR causes defects in the embryonic heart but not visceral mesoderm.

      (Ranganayakulu et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Mmus\Nkx2-5UAS.cRa, Scer\GAL4Mef2.PR, Scer\GAL4twi.PB has visceral mesoderm phenotype, suppressible | partially by tinEC40

      (Ranganayakulu et al., 1998)

      Mmus\Nkx2-5UAS.cRa, Scer\GAL4Mef2.PR, Scer\GAL4twi.PB has embryonic/larval heart & mesoderm phenotype, suppressible | partially by tinEC40

      (Ranganayakulu et al., 1998)
      Suppressor of
      Statement
      Reference

      Scer\GAL4twi.PB, Scer\GAL4Mef2.PR, Mmus\Nkx2-5UAS.cRa is a suppressor of visceral mesoderm phenotype of tinEC40

      (Ranganayakulu et al., 1998)

      Scer\GAL4twi.PB, Scer\GAL4Mef2.PR, Mmus\Nkx2-5UAS.cRa is a suppressor of embryonic/larval heart & mesoderm phenotype of tinEC40

      (Ranganayakulu et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression driven by Scer\GAL4twi.PB and Scer\GAL4Mef2.PR partially suppresses the phenotypic defects of tinEC40 : visceral but not somatic or cardiac mesoderm is rescued.

      (Ranganayakulu et al., 1998)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mmus\Nkx2-5Scer\UAS.cRa
      Mmus\Nkx2-5UAS.cRa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ranganayakulu
      (Ranganayakulu et al., 1998)
      Secondary FlyBase IDs
        References (1)