FB2024_03 , released June 25, 2024
Allele: Dmel\tin::MmusNkx2-5UAS.tin-Nkx
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General Information
Symbol
Dmel\tin::Mmus\Nkx2-5UAS.tin-Nkx
Species
D. melanogaster
Name
FlyBase ID
FBal0092494
Feature type
allele
Associated gene
tin::Mmus\Nkx2-5
Associated Insertion(s)
Carried in Construct
P{UAS-N,HD-tin/C-Nkx.R}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ranganayakulu et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-N,HD-tin/C-Nkx.R}
Cytology
Description

A fusion between amino acids 1-345 of tin and amino acids 184-318 of Mmus\Nkx2-5 is expressed under the control of UASt regulatory sequences. The homeodomain has amino acids 55-60 altered from SKRGD to CKRQR.

(Ranganayakulu et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tin::Mmus\Nkx2-5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4twi.PB, tin::Mmus\Nkx2-5UAS.tin-Nkx, Scer\GAL4Mef2.PR is a suppressor of visceral mesoderm phenotype of tinEC40

      (Ranganayakulu et al., 1998)

      Scer\GAL4twi.PB, tin::Mmus\Nkx2-5UAS.tin-Nkx, Scer\GAL4Mef2.PR is a suppressor of embryonic/larval heart & mesoderm phenotype of tinEC40

      (Ranganayakulu et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rescues cardiac and visceral mesoderm defects of tinEC40 when expression is driven by Scer\GAL4twi.PB and Scer\GAL4Mef2.PR.

      (Ranganayakulu et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tin::Mmus\Nkx2-5Scer\UAS.tin-Nkx
      tin::Mmus\Nkx2-5UAS.tin-Nkx
      Name Synonyms
      Secondary FlyBase IDs
        References (1)