FB2024_03 , released June 25, 2024
Allele: Dmel\stauΔdRBD5.αTub67C.Tag:MYC
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General Information
Symbol
Dmel\stauΔdRBD5.αTub67C.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0091178
Feature type
allele
Associated gene
Dmel\stau
Associated Insertion(s)
Carried in Construct
P{αTub67C-stau.ΔdRBD5}
Key Links
Transgenic product class
inframe_deletion
(Schuldt et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Schuldt et al., 1998)
Mutagen
in vitro construct
(Micklem et al., 2000, Schuldt et al., 1998)
Progenitor genotype
Carried in construct
P{αTub67C-stau.ΔdRBD5}
Cytology
Description

A deleted form of stau lacking the carboxy-terminal 157 amino acids (lacks dsRNA binding Domain 5), tagged at the amino terminal end with Tag:MYC, is expressed under the control of a αTub67C promoter.

(Schuldt et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
αTub67C
Encoded product / tool
stau
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      stauΔdRBD5.αTub67C.Tag:MYC/stau2 is a suppressor of visible | homeotic phenotype of miraαTub67C.mGFP6

      (Irion et al., 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos that express both miraαTub67C.T:Avic\GFP-m6 and stauΔdRBD5.αTub67C.T:Hsap\MYC in a stau2 background show the stauΔdRBD5.αTub67C.T:Hsap\MYC posterior group phenotype in which embryos develop a normal head and thorax, but lack the abdomen.

      (Irion et al., 2006)

      stau2, oskΔBRE, stauΔdRBD5.αTub67C.T:Hsap\MYC mothers lay embryos with significantly more abdominal denticle belts than seen in stau2,oskΔBRE alone.

      (Micklem et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      stauΔdRBD5.αTub67C.Tag:MYC partially rescues stau2

      (Micklem et al., 2000)
      Comments

      The addition of stauΔdRBD5.αTub67C.T:Hsap\MYC to stau2 mothers, produces embryos that show almost no rescue of the stau2 abdominal phenotype. However, the head skeleton defects seen in stau2 flies are rescued: 2/3 of embryos have wild-type heads (compared to none in stau2 alone) and the rest have much milder head defects.

      (Micklem et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      stauΔdRBD5.αTub67C.T:Hsap\MYC
      stauΔdRBD5.αTub67C.T:Myc
      stauΔdRBD5.αTub67C.Tag:MYC
      stauΔdRBD5
      (Irion et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)