FB2024_03 , released June 25, 2024
Allele: Dmel\N::sevSev11.GV.3.hs
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General Information
Symbol
Dmel\N::sevSev11.GV.3.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0090677
Feature type
allele
Associated gene
N::sev
Associated Insertion(s)
Carried in Construct
P{NSev11-GV.3}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Struhl and Adachi, 1998)
Progenitor genotype
NGV.3.hs
(Struhl and Adachi, 1998)
Carried in construct
P{NSev11-GV.3}
Cytology
Description

The EGF repeats, LNR and transmembrane domain of NGV.3.hs have been replaced by the extracellular and transmembrane domains of the truncated form of the S11 sev protein.

(Struhl and Adachi, 1998)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
N::sev
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of N::sevSev11.3.hs.T:Scer\GAL4,T:Hsim\VP16 using heat shock (either 1 or 2 hours) during the third instar larval stage does not cause a rough eye phenotype.

      (Cho and Fischer, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      N::sevSev11.GV.3.hs is an enhancer | heat sensitive of visible phenotype of RalaEE1

      (Cho and Fischer, 2011)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      N::sevSev11.GV.3.hs is an enhancer | heat sensitive of eye phenotype of RalaEE1

      (Cho and Fischer, 2011)
      NOT Suppressor of
      Statement
      Reference

      N::sevSev11.GV.3.hs is a non-suppressor of phenotype of NXK11

      (Struhl and Adachi, 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of N::sevSev11.3.hs.T:Scer\GAL4,T:Hsim\VP16 using heat shock (either 1 or 2 hours) during the third instar larval stage enhances the rough eye phenotype of RalaEE1/Y.

      (Cho and Fischer, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      GAL4::N::sev::VP16Sev11.3.hs
      N::sevSev11.3.hs.T:Scer\GAL4,T:Hsim\VP16
      N::sevSev11.GV.3.hs
      NSev11-GV#3
      (Struhl and Adachi, 1998)
      NSev11-GV3
      (Chan and Jan, 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)