FB2024_03 , released June 25, 2024
Allele: Dmel\mlt4210
Open Close
General Information
Symbol
Dmel\mlt4210
Species
D. melanogaster
Name
FlyBase ID
FBal0090223
Feature type
allele
Associated gene
Dmel\mlt
Associated Insertion(s)
P{lacW}mlt4210
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Fabrizio et al., 1998)
Progenitor genotype
Associated Insertion(s)
P{lacW}mlt4210
Cytology
Description

Insertion at nucleotide 2R:6046076 (release 5 coordinates), within a region common to the 5' UTR of all three mlt isoforms.

(Fabrizio et al., 2012)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Individualisation complexes assembled around spermatid nuclear bundles are intact in mltEY02157/mlt4210 testes, but progressed individualisation complexes (those no longer co-localising with the nuclear bundle) are often disrupted, having one or more investment cones out of register. Sleeves of F-actin associated with highly condensed spermatid bundles at the most basal end of the testis tubule are sometimes seen.

      (Fabrizio et al., 2012)

      Mutants show male sterility, with highly elongated, immobile, blebbed sperm tails and altered individualisation complexes. Individualisation complexes form normally but degrade as they proceed caudally along the cyst.

      (Fabrizio et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mutation is revertible on introduction of P{Δ2-3}.

      (Fabrizio et al., 1998)

      Although the P{lacW}mlt4210 insertion maps within both 5'UTR of the CG12214 annotation and an intron of KCNQ (nested genes, CG12214 is entirely within a large intron of KCNQ), complementation analysis indicates that the "mlt" mutant phenotype caused by this insertion (spermatid individualisation defects) is due to an effect on CG12214 and not on KCNQ.

      (Fabrizio et al., 2012)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mlt4210
      ms(2)4210
      (Fabrizio et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)