FlyBase Allele Report: Dmel\rl[Sem.MB.UAS]

General Information

Symbol

Dmel\rl^Sem.MB.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0090164

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

P{UAS-rl.Sem.MB}

Also Known As

UAS-rl^sem

Key Links

Transgenic product class

missense_variant

(Martin-Blanco, 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Martin-Blanco, 1998)

Mutagen

in vitro construct

(Martin-Blanco, 1998)

Progenitor genotype

Carried in construct

P{UAS-rl.Sem.MB}

Cytology

Description

An activated form of rl is expressed under the control of UAS regulatory sequences.

(Martin-Blanco, 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | pupal stage, with Scer\GAL4^Ras64B.PW

(Gouzi et al., 2011)

decreased cell size | adult stage

(Gouzi et al., 2011)

visible, with Scer\GAL4^455.2

(Martin-Blanco, 1998)

visible, with Scer\GAL4⁶⁰⁴

(Martin-Blanco, 1998)

visible, with Scer\GAL4^dpp.blk1

(Kim et al., 2012)

visible | adult stage, with Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

Phenotype Manifest In

wing

(Gouzi et al., 2011)

wing, with Scer\GAL4^455.2

(Martin-Blanco, 1998)

wing, with Scer\GAL4⁶⁰⁴

(Martin-Blanco, 1998)

wing, with Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

wing vein, with Scer\GAL4^455.2

(Martin-Blanco, 1998)

wing vein, with Scer\GAL4⁶⁰⁴

(Martin-Blanco, 1998)

wing vein | ectopic, with Scer\GAL4^dpp.blk1

(Kim et al., 2012)

wing vein | ectopic, with Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

Detailed Description

Statement

Reference

Overexpression of rl^Sem.Scer\UAS under the control of Scer\GAL4^dpp.blk1 produces extra wing veins at the anterior-posterior compartment boundary.

(Kim et al., 2012)

Expression of rl^Sem.Scer\UAS under the control of Scer\GAL4^Ras64B.PW results in small animals with small wings due to a reduction in cell size but not cell number.

(Gouzi et al., 2011)

Expression of rl^Sem.MB.UAS under the control of Scer\GAL4^sd.PU leads to a strong ectopic wing vein phenotype with one or two wings exhibiting blisters in most of the flies.

(Mouchel-Vielh et al., 2011)

Expression of rl^Sem.Scer\UAS under the control of Scer\GAL4^dpp.blk1 does not result in ectopic furrow formation in the eye disc.

(Kumar and Moses, 2001)

Flies expressing rl^Sem.Scer\UAS under the control of Scer\GAL4⁶⁰⁴ have extra wing vein tissue. Flies expressing rl^Sem.Scer\UAS under the control of Scer\GAL4^455.2 have extra wing vein tissue.

(Martin-Blanco, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^dpp.blk1, rl^Sem.MB.UAS has visible phenotype, suppressible | partially by Scer\GAL4^dpp.blk1/pum^UAS.cKa

(Kim et al., 2012)

Scer\GAL4^sd.PU, rl^Sem.MB.UAS has visible | adult stage phenotype, suppressible | partially by corto[+]/corto⁴²⁰

(Mouchel-Vielh et al., 2011)

Scer\GAL4^sd.PU, rl^Sem.MB.UAS has visible | adult stage phenotype, suppressible | partially by corto^07128b/corto[+]

(Mouchel-Vielh et al., 2011)

Scer\GAL4^455.2, rl^Sem.MB.UAS has visible phenotype, suppressible by puc^UAS.cMa/Scer\GAL4^455.2

(Martin-Blanco, 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^dpp.blk1, rl^Sem.MB.UAS has wing vein | ectopic phenotype, suppressible | partially by Scer\GAL4^dpp.blk1/pum^UAS.cKa

(Kim et al., 2012)

Scer\GAL4^sd.PU, rl^Sem.MB.UAS has wing phenotype, suppressible | partially by corto[+]/corto⁴²⁰

(Mouchel-Vielh et al., 2011)

Scer\GAL4^sd.PU, rl^Sem.MB.UAS has wing phenotype, suppressible | partially by corto^07128b/corto[+]

(Mouchel-Vielh et al., 2011)

Scer\GAL4^455.2, rl^Sem.MB.UAS has wing phenotype, suppressible by puc^UAS.cMa/Scer\GAL4^455.2

(Martin-Blanco, 1998)

Scer\GAL4^455.2, rl^Sem.MB.UAS has wing vein phenotype, suppressible by puc^UAS.cMa/Scer\GAL4^455.2

(Martin-Blanco, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Co-overexpression of pum^Scer\UAS.cKa with rl^Sem.Scer\UAS under the control of Scer\GAL4^dpp.blk1 suppresses the ectopic wing veins caused by overexpression of rl^Sem.Scer\UAS alone.

(Kim et al., 2012)

Either corto⁴²⁰/+ or corto^07128b/+ lowers penetrance and expressivity of the blistered wing phenotype induced by expression of rl^Sem.MB.UAS under the control of Scer\GAL4^sd.PU.

(Mouchel-Vielh et al., 2011)

puc^Scer\UAS.cMa suppresses the extra wing vein phenotype of flies expressing rl^Sem.Scer\UAS under the control of Scer\GAL4^455.2.

(Martin-Blanco, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

rl^Sem.MB.UAS

rl^Sem.Scer\UAS

rl^Sem.UAS

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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