FB2024_03 , released June 25, 2024
Allele: Dmel\numbfl.UAS.Tag:MYC
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General Information
Symbol
Dmel\numbfl.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0088741
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
P{UAS-numb.T:Myc.Y}
Also Known As
UAS-Numb-myc, UAS-Myc-Numb, UAS-numb
Key Links
Transgenic product class
cDNA
(Yaich et al., 1998)
wild_type
(Yaich et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Yaich et al., 1998)
wild_type
(Yaich et al., 1998)
Mutagen
in vitro construct
(Park et al., 1998, Yaich et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-numb.T:Myc.Y}
Cytology
Description

Full length wild-type numb cDNA, tagged at the C-terminus with Tag:MYC, is expressed under the control of UASt regulatory sequences.

(Yaich et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
numb
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of numbfl.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4neur-P72 induces a premature movement of both the anterior and posterior centrosomes during cytokinesis in pI (sensory organ precursor) cells in the notum, and an absence of difference in their timing of apical movements, in contrast to the centrosome asymmetry seen during cytokinesis in wild-type pI cells.

      (Jauffred et al., 2013)

      When numbfl.Scer\UAS.T:Hsap\MYC is driven by Scer\GAL4eve.eme a loss of eve expressing pericardial cells is seen. Instead two pairs of DA1 and DO2 muscle founders are seen.

      (Han and Bodmer, 2003)

      spi1 embryos in which numbfl.Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4how-24B and Scer\GAL4twi.PG lack the eve-expressing pericardial cells and DA1 muscles.

      (Su et al., 1999)

      Embryos expressing numbfl.Scer\UAS.T:Hsap\MYC under the control of both Scer\GAL4how-24B and Scer\GAL4twi.PG form DA1 muscles but the number of eve-expressing pericardial cells is drastically reduced.

      (Park et al., 1998)

      76-100% of macrochaetae are missing in most lines of flies expressing numbfl.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4189. Overexpression of numbfl.Scer\UAS.T:Hsap\MYC using Scer\GAL4C96 results in twinning of bristles on the wing margin.

      (Yaich et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overproliferation of neuroblasts seen in the larval brain in animals expressing aPKCCAAXWT.Scer\UAS under the control of Scer\GAL41407 at 29[o]C is suppressed by co-expression of numbfl.Scer\UAS.T:Hsap\MYC.

      (Wirtz-Peitz et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      numbfl.Scer\UAS.T:Hsap\MYC
      numbfl.UAS.T:Myc
      numbfl.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (14)