FB2024_03 , released June 25, 2024
Allele: Dmel\IKKβ1
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General Information
Symbol
Dmel\IKKβ1
Species
D. melanogaster
Name
FlyBase ID
FBal0086536
Feature type
allele
Associated gene
Dmel\IKKβ
Associated Insertion(s)
Carried in Construct
Also Known As
ird51, DmIkkβird5
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Lu et al., 2001)
Mutagen
ethyl methanesulfonate
(Wu and Anderson, 1998)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Lu et al., 2001)

Amino acid replacement: Q266term.

(Lu et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:16,048,218..16,048,218 [-]
Nucleotide change:

C16048218T

Reported nucleotide change:

C?T

Amino acid change:

Q232term | IKKbeta-PB

Reported amino acid change:

Q266term

(Lu et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      IKKβ1/Df(3R)Exel7328 transheterozygotes infected with DCV show a significantly decreased lifespan and a severe increase in viral load, as compared to infected controls.

      (Goto et al., 2018)

      IKKβ1 mutants are significantly more likely to die from Serratia marcescens infection than their wild-type counterparts.

      (Bandarra et al., 2015)

      IKKβ1 mutants exhibit a significant reduction in survival under hypoxic conditions, as compared to controls.

      (Bandarra et al., 2014)

      Mutants show no detectable induction of Dpt, CecA1 and CecA2. Attacin levels are reduced compared to wild type and Drs induction is normal. Bacteria injected into mutant larvae show increased survival compared to those injected into wild type: 6hr after infection 4-15 times as many bacteria survive in mutants than in wild type. In adults, 24hr after infection 20-350 times as many bacteria survive in mutants than in wild type. Phenotype is similar to that shown by Rel mutants and stronger than that shown by imd mutants. A small fraction (0.5%) of embryos produced by homozygous ird51 mothers or ird51/ird52 transheterozygotes show weakly dorsalized phenotypes.

      (Lu et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      DmIKKβird5
      (Vidal et al., 2001)
      DmIkkβird5
      (Khush et al., 2002)
      IKKβ1
      (Collins et al., 2023, Padash Barmchi et al., 2021)
      Ird51
      (Bandarra et al., 2014)
      ird51
      (Goto et al., 2018, Nandy et al., 2018, Bandarra et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)