FB2024_03 , released June 25, 2024
Allele: Dmel\zfh165.34
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General Information
Symbol
Dmel\zfh165.34
Species
D. melanogaster
Name
FlyBase ID
FBal0086261
Feature type
allele
Associated gene
Dmel\zfh1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Broihier et al., 1998)

amorphic allele - molecular evidence

(Leatherman and DiNardo, 2008)
Mutagen
ethyl methanesulfonate
(Broihier et al., 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Very few zfh165.34 mutant cyst progenitor cell clones are recovered compared to controls. Germline stem cell clones are recovered at similar levels to controls.

      (Leatherman and DiNardo, 2008)

      Mutant embryos have mild defects in the development of the tracheal dorsal trunk.

      (Franch-Marro and Casanova, 2000)

      Germ cells in mutant embryos do not successfully navigate to the somatic gonadal precursors (SGPs): the majority of the germ cells do not attach to the SGPs at stage 11. Germ cells migrate past their target mesodermal cells, into posterior or ectodermal regions. Occasionally small gonads may form. Embryos derived from homozygous germline clones develop normally as long as a wild-type copy of zfh1 is zygotically provided. The germ cell migration phenotype is not exacerbated when the embryos are derived from a zfh1 homozygous mutant germline. Germ cells are unable to transfer between germ layers in double mutant embryos with tin (Df(3R)GC14). Most germ cells adhere to the endoderm throughout embryogenesis, some scatter near the gut at late stages.

      (Broihier et al., 1998)

      The number of fat body precursor cells is reduced in zfh165.34/zfh175.26 embryos, often resulting in gaps within the developing tissue.

      (Moore et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of tinEC40 to mutants leads to a tracheal dorsal trunk that is almost completely absent.

      (Franch-Marro and Casanova, 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      zfh165.34/zfh175.26 is rescued by zfh1hs.PL

      (Broihier et al., 1998)
      Comments

      Germ cell migration phenotype is rescued by heat induced ectopic expression of zfh1hs.PL.

      (Broihier et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      zfh-165.34
      (Leatherman and DiNardo, 2008)
      zfh165.34
      (Wu et al., 2019, Flaherty et al., 2010, Garces and Thor, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)