FlyBase Allele Report: Dmel\ss[aSc]

General Information

Symbol

Dmel\ss^aSc

Species

D. melanogaster

Name

FlyBase ID

FBal0083730

Feature type

allele

Associated gene

Dmel\ss

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Kuzin et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Kuzin et al., 1997)

decreased occurrence of cell division

(Kuzin et al., 1997)

increased occurrence of cell division

(Kuzin et al., 1997)

Phenotype Manifest In

antennal segment

(Kuzin et al., 1997)

arista

(Kuzin et al., 1997)

macrochaeta

(Kuzin et al., 1997)

mesothoracic leg disc | larval stage

(Kuzin et al., 1997)

metathoracic leg disc | larval stage

(Kuzin et al., 1997)

prothoracic leg disc | larval stage

(Kuzin et al., 1997)

sex comb

(Kuzin et al., 1997)

tarsal segment

(Kuzin et al., 1997)

Detailed Description

Statement

Reference

Homozygous mutants exhibit the classical ss traits: reduced bristle size, transformation of distal antennal parts into the tarsal segments of the mesothoracic leg and fusion of tarsal segments in legs and in transformed aristae. Mutation is also characterised by amplification of the sex combs of the first tarsal segment on the first leg in male homozygotes. Transplantation of leg imaginal discs into ready-to-pupate Oregon R larvae demonstrates the proliferation of cells that form the metatarsus is suppressed, whereas cells that give rise to the proximal parts of the tarsus proliferate at an excessive rate.

(Kuzin et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

mil^aSc, ss^aSc has radiation sensitive phenotype

(Kuzin et al., 2014)

Antp^hs.PHTA, ss^aSc has visible phenotype

(Kuzin et al., 1997)

Antp^hs.PHTA, ss^aSc has abnormal size | adult stage phenotype

(Kuzin et al., 1997)

Dfd^hs.PK, ss^aSc has abnormal size | adult stage phenotype

(Kuzin et al., 1997)

lab^hs.PH, ss^aSc has abnormal size | adult stage phenotype

(Kuzin et al., 1997)

Dfd^hs.PK, ss^aSc has visible phenotype

(Kuzin et al., 1997)

lab^hs.PH, ss^aSc has visible phenotype

(Kuzin et al., 1997)

Phenotype Manifest In

Other

Statement

Reference

Antp^hs.PHTA, ss^aSc has tarsal segment phenotype

(Kuzin et al., 1997)

lab^hs.PH, ss^aSc has antennal segment 3 & macrochaeta phenotype

(Kuzin et al., 1997)

Antp^hs.PHTA, ss^aSc has third segment of antenna phenotype

(Kuzin et al., 1997)

Antp^hs.PHTA, ss^aSc has second segment of antenna phenotype

(Kuzin et al., 1997)

Dfd^hs.PK, ss^aSc has tarsal segment phenotype

(Kuzin et al., 1997)

Dfd^hs.PK, ss^aSc has third segment of antenna phenotype

(Kuzin et al., 1997)

lab^hs.PH, ss^aSc has tarsal segment phenotype

(Kuzin et al., 1997)

lab^hs.PH, ss^aSc has antennal segment phenotype

(Kuzin et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

mil^aSc ss^aSc double mutant flies show increased sensitivity to even low doses of X ray irradiation (1 and 10 R), which is manifested as an increase in defects in the antenna and legs.

(Kuzin et al., 2014)

Induction of Antp^hs.PHTA expression causes severe tarsal defects, tarsal structures resemble mini-tibia. Antennal structures look unusual due to overgrowth of the second and third antennal segments and proximal structures of the homeo tarsus. Induction of Dfd^hs.PK expression causes overgrowth of the third antennal segment and of proximal parts of the homeo tarsus. Legs exhibit enlargement of the proximal part of the tarsus. Induction of lab^hs.PH expression causes shortening of tarsi in all antennal and leg structures. Third segment of the antenna exhibits a multiple bristle phenotype.

(Kuzin et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: mil^aSc.

(Kuzin et al., 2014)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ss^aSc

(Akishina et al., 2018, Kuzin et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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