FlyBase Allele Report: Dmel\mira[RR127]

General Information

Symbol

Dmel\mira^RR127

Species

D. melanogaster

Name

FlyBase ID

FBal0082442

Feature type

allele

Associated gene

Dmel\mira

Associated Insertion(s)

Carried in Construct

Also Known As

miranda^RR127

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Ikeshima-Kataoka et al., 1997)

Mutagen

ethyl methanesulfonate

(Ikeshima-Kataoka et al., 1997)

Progenitor genotype

Cytology

Description

Deletion of nucleotides 2426-2435, which results in a frameshift after amino acid residue 727 (the protein produced contains 112 novel amino acid residues, which are RSCDPTARRSPRGCSTPRTSACARIPPARSTSSCPPASPRPVPPPAHPRRRRTPRAVRAPPTPHEHHDRRPALPRRLSCSPARRTCPVRHRSRCSRRATSRLFLCNNYSIVLL).

(Fuerstenberg et al., 1998)

10bp deletion that induces a frameshift replacing the C-terminal 103 amino acids with an unrelated stretch of 112 amino acids.

(Ikeshima-Kataoka et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:19,932,490..19,932,492 [-]

Comment:

A 10bp deletion induces a frameshift that replaces the C-terminal 103 amino acids with an unrelated stretch of 112 amino acids

(Ikeshima-Kataoka et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Berger et al., 2010)

lethal | recessive

(Ikeshima-Kataoka et al., 1997)

Phenotype Manifest In

embryonic/larval glial cell

(Akiyama-Oda et al., 2000)

larval longitudinal connective

(Ikeshima-Kataoka et al., 1997)

neuroblast NB6-4

(Berger et al., 2010)

symmetrical commissure

(Ikeshima-Kataoka et al., 1997)

thoracic neuroblast NB6-4

(Akiyama-Oda et al., 2000)

Detailed Description

Statement

Reference

mira^RR127 embryos exhibit neuronal-only identity of the NB6-4t lineage.

(Berger et al., 2010)

All progeny of NB6-4T adopt a neuronal cell fate, failing to express gcm and repo and retaining a lateral position. This phenotype is similar to that shown by pros mutants.

(Akiyama-Oda et al., 2000)

Axon tracts of embryos are grossly defective, longitudinal connectives are generally broken or severely reduced in width and commissures are partially or completely fused. Phenotype milder than for mira^L44 and mira^ZZ176.

(Ikeshima-Kataoka et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mira^L44

(Ikeshima-Kataoka et al., 1997)

mira^ZZ176

(Ikeshima-Kataoka et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

One of a group of six alleles isolated in the same screen.

(Ikeshima-Kataoka et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Mir^RR127

(Fuerstenberg et al., 1998)

mira^RR127

(Berger et al., 2010)

miranda^RR127

(Slack et al., 2007, Fuerstenberg et al., 1998)

miranda^RR

(Fuerstenberg et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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