FB2024_03 , released June 25, 2024
Allele: Dmel\msl-2M63
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General Information
Symbol
Dmel\msl-2M63
Species
D. melanogaster
Name
FlyBase ID
FBal0082430
Feature type
allele
Associated gene
Dmel\msl-2
Associated Insertion(s)
Carried in Construct
P{msl-2M63}
Key Links
Genomic Maps

Transgenic product class
inframe_deletion
(Lyman et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Lyman et al., 1997)
Mutagen
ethyl methanesulfonate
(Lyman et al., 1997)
Progenitor genotype
msl-2Hsp83.PK
(Lyman et al., 1997)
Carried in construct
P{msl-2M63}
Cytology
Description

In frame deletion of 121 amino acids resulting in a protein lacking residues 19-140, including the RING finger (residues 39-82).

(Lyman et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp83
Encoded product / tool
msl-2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:3,465,219..3,465,585 [-]
Comment:

in frame deletion of 121 amino acids resulting in a protein lacking residues 19-140, including the RING finger (residues 39-82).

(Lyman et al., 1997)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Suppression of the lethality and late eclosion phenotype of msl-2Hsp83.PK females. Protein fails to bind the X chromosome in transgenic females or complement msl-2 mutant males.

      (Lyman et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      msl-2M63
      Name Synonyms
      Secondary FlyBase IDs
        References (2)