FlyBase Allele Report: Dmel\wg[PE2.UAS]

General Information

Symbol

Dmel\wg^PE2.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0065599

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

P{UAS-wg.PE2}

Key Links

Transgenic product class

missense_variant

(Hays et al., 1997)

Mutagen

FLPase

Nature of the Allele

Transgenic product class

missense_variant

(Hays et al., 1997)

Mutagen

FLPase

(Hays et al., 1997)

Progenitor genotype

wg^PE2.FRT.UAS

(Hays et al., 1997)

Carried in construct

P{UAS-wg.PE2}

Cytology

Description

The FRT cassette has been excised, juxtaposing UASt regulatory sequences and mutant wg coding sequences.

(Hays et al., 1997)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval epidermis, with Scer\GAL4^e22c

(Moline et al., 2000)

ventral denticle belt, with Scer\GAL4^e22c

(Moline et al., 2000)

Detailed Description

Statement

Reference

Overexpression of wg^PE2.Scer\UAS driven by Scer\GAL4^e22c slightly disrupts denticle pattern and naked cuticle formation.

(Moline et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^e22c, wg^PE2.UAS has embryonic/larval epidermis phenotype, enhanceable by fz2^UAS.cZa/Scer\GAL4^e22c

(Moline et al., 2000)

Scer\GAL4^e22c, wg^PE2.UAS has ventral denticle belt phenotype, enhanceable by fz2^UAS.cZa/Scer\GAL4^e22c

(Moline et al., 2000)

Suppressed by

Statement

Reference

Scer\GAL4^e22c, wg^PE2.UAS has ventral denticle belt phenotype, suppressible | partially by fz^UAS.cZa/Scer\GAL4^e22c

(Moline et al., 2000)

Scer\GAL4^e22c, wg^PE2.UAS has embryonic/larval epidermis phenotype, suppressible | partially by fz^UAS.cZa/Scer\GAL4^e22c

(Moline et al., 2000)

Enhancer of

Statement

Reference

wg^PE2.UAS/Scer\GAL4^e22c is an enhancer of embryonic/larval epidermis phenotype of Scer\GAL4^e22c, fz2^UAS.cZa

(Moline et al., 2000)

wg^PE2.UAS/Scer\GAL4^e22c is an enhancer of ventral denticle belt phenotype of Scer\GAL4^e22c, fz2^UAS.cZa

(Moline et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Over expression of fz2^Scer\UAS.cZa and wg^PE2.Scer\UAS driven by Scer\GAL4^e22c produces uniformly naked cuticle. Over expression of fz^Scer\UAS.cZa and wg^PE2.Scer\UAS driven by Scer\GAL4^e22c slightly suppresses the denticle phenotype.

(Moline et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

wg^PE2.UAS/Scer\GAL4^e22c rescues wg^l-17

(Moline et al., 2000)

Partially rescues

wg^PE2.UAS/Scer\GAL4^wg.PM partially rescues wg^l-17

(Hays et al., 1997)

wg^PE2.UAS/Scer\GAL4^e22c partially rescues wg^l-17

(Hays et al., 1997)

Comments

wg^PE2.Scer\UAS rescues denticle diversity in wg^l-17 larvae when driven by Scer\GAL4^e22c.

(Moline et al., 2000)

Expression of wg^PE2.Scer\UAS using Scer\GAL4^e22c in wg^l-17 embryos restores denticle diversity, but there is no specification of naked cuticle along the ventral midline. Expression of wg^PE2.Scer\UAS using Scer\GAL4^wg.PM in wg^l-17 embryos rescues denticle diversity, but there is no specification of naked cuticle.

(Hays et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Exists in clones, not reported as being germ-line transmitted.

(Hays et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wg^PE2.Scer\UAS

wg^PE2.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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