FB2024_03 , released June 25, 2024
Allele: Dmel\DrlacZ-Δ89
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General Information
Symbol
Dmel\DrlacZ-Δ89
Species
D. melanogaster
Name
FlyBase ID
FBal0063862
Feature type
allele
Associated gene
Dmel\Dr
Associated Insertion(s)
P{5'lacZ}DrlacZ-Δ89
Carried in Construct
Also Known As
mshlacZ-Δ89, msh-lacZ, mshΔ89-lacZ
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Isshiki et al., 1997)
Progenitor genotype
P{lacZ.ry+}DrrH96
(Isshiki et al., 1997)
Associated Insertion(s)
P{5'lacZ}DrlacZ-Δ89
Cytology
Description

Imprecise excision of the P{lacZ} element, deleting a portion of the Dr coding region. The 5' end of the P{lacZ} element, including the Ecol\lacZ coding region, is still present.

(Isshiki et al., 1997)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DrlacZ-Δ89 heterozygous stage 15 embryos do not exhibit any obvious mutant phenotype in the central nervous system.

      Homozygous DrlacZ-Δ89 stage 15 mutants display a lack of tritocerebral neuronal tissue.

      An increase in apoptosis compared to controls is seen in the basal procephalic longitudinal glia cluster and the deuto-/tritocerebral fibre tract founder cluster in stage 12 DrlacZ-Δ89 embryos.

      (Sprecher and Hirth, 2006)

      DrlacZ-Δ89 mutants have supernumerary cardioblasts and pericardial cells, which lead to an enlarged heart.

      (Jagla et al., 2002)

      The longitudinal glioblast (LGB) forms normally and undergoes a normal first cell division in homozygous embryos, although further cell division and migration of the progeny is abnormal.

      (Isshiki et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      DrlacZ-Δ89
      mshlacZ-Δ89
      (Sprecher and Hirth, 2006, Nose et al., 1998, Isshiki et al., 1997)
      mshlacZ-δ89
      (Sprecher and Hirth, 2006)
      mshΔ89
      (Jagla et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)