FB2024_03 , released June 25, 2024
Allele: Dmel\pum04277
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General Information
Symbol
Dmel\pum04277
Species
D. melanogaster
Name
FlyBase ID
FBal0060927
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
pum4277
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P{PZ} insertion in the intron between exons 8 and 9. The orientation of the P{PZ} element is such that the ry marker gene is towards the 5' side of the pum gene while the Ecol\lacZ gene is oriented towards the 3' side.

Allele components
Component
Use(s)
Inserted element
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

More than 50% of homozygous larvae survive the pupal stage to eclosion. Homozygous ovaries from third instar larvae have an overproliferated germline. By the adult stage, 89% of homozygous females have "differentiated ovaries" (containing recognisable egg chambers and/or germline cells in at least one ovariole) and 11% of females have one germlineless and one differentiated ovary. Developing mutant egg chambers sometimes contain few nurse cells but no oocytes. The number of ring canals is reduced in these egg chambers and there is a pronounced unequal ploidy among the nurse cells. Somatic defects are also detected at a low frequency, such as long interfollicular stalks and the disruption of single-stack cells in the terminal filament.

Small ovary phenotype.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
fs(3)04277
pum04277
Name Synonyms
Secondary FlyBase IDs
    References (3)