FB2024_03 , released June 25, 2024
Allele: Dmel\Cdk1G177E
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General Information
Symbol
Dmel\Cdk1G177E
Species
D. melanogaster
Name
FlyBase ID
FBal0060476
Feature type
allele
Associated gene
Dmel\Cdk1
Associated Insertion(s)
Carried in Construct
P{G177E}
Key Links
Transgenic product class
missense_variant
(Sigrist et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Sigrist et al., 1995)
Mutagen
in vitro construct
(Sigrist et al., 1995)
Progenitor genotype
Cdk1+t5.8
(Sigrist et al., 1995)
Carried in construct
P{G177E}
Cytology
Description

Mutation within the conserved region of a 5.8kb HindIII Cdk1 genomic fragment (amino acid replacement G177E), mutation corresponds to a known temperature sensitive allele of S. pombe cdc2.

(Sigrist et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
Cdk1
Encoded product / tool
Cdk1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Cdk1G177E partially rescues Cdk1216P/Df(2L)J27

      (Sigrist et al., 1995)
      Fails to rescue

      Cdk1G177E fails to rescue Cdk1E1-23/Df(2L)J27

      (Sigrist et al., 1995)

      Cdk1G177E fails to rescue Cdk1B47/Df(2L)J27

      (Sigrist et al., 1995)
      Comments

      Provides little activity at high or low temperatures.

      (Sigrist et al., 1995)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Cdk1G177E
      Dmcdc2G177E
      (Sigrist et al., 1995)
      cdc2G177E
      Name Synonyms
      Secondary FlyBase IDs
        References (1)