FB2024_03 , released June 25, 2024
Allele: Dmel\hhMir
Open Close
General Information
Symbol
Dmel\hhMir
Species
D. melanogaster
Name
Mirabile
FlyBase ID
FBal0060396
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Kopp et al., 1999, Kopp, 1997.5.28, Kopp and Duncan, 1997, Kopp et al., 1997, Kopp et al., 1997)
Mutagen
X ray
(Kopp et al., 1997)
Progenitor genotype
Caused by aberration
T(1;3)Mir
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The anterior tergite is deleted and replaced by a mirror-image duplication of the intersegmental membrane (ISM), posterior hairy zone (PHZ) and posterior tergite.

      (Kopp and Duncan, 1997)

      Causes the duplication of posterior structures anteriorly in each abdominal segment.

      (Kopp et al., 1997)

      The anterior region of the abdominal tergites is missing in heterozygous adults, and is replaced by a mirror-image duplication of the posterior region of the tergite and intertergal region. Internally, the oenocytes underlying the posterior region of the tergite are also duplicated and the insertion points of the adult muscles reflect the symmetrical epidermal pattern.

      (Kopp et al., 1997)

      Mirror-image duplication of tergite structure. Microchaetae are eliminated from the anterior portion of the tergite and replaced by a duplication consisting of an anteriorly oriented row of macrochaetae and the darkly pigmented cuticle normally found in the posterior portion of the tergite. Fat body and oenocytes underneath the tergite are also duplicated with mirror-image symmetry (Madhavan and Madhavan). Dominant and revertable by X ray mutagenesis suggesting that this allele constitutes a gain-of-function mutation.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      hhMir has visible | dominant phenotype, suppressible by biomb-282

      (Kopp and Duncan, 1997)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      hhMir has tergite phenotype, suppressible by biomb-282

      (Kopp and Duncan, 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The phenotypes in the tergite and PHZ are suppressed by biomb-282; in biomb-282 ; hhMir double mutants, both the normal and mirror-image duplicated PHZ and posterior tergite structures are missing and replaced with a mirror-image double anterior pattern similar to biomb-282 single mutants. However, all segments show double anterior patterning in the double mutants, whereas mirror-image duplications are only seen in a fraction of the segments in biomb-282 single mutants. biomb-282 does not suppress the formation of ectopic ISM seen in hhMir/+ flies.

      (Kopp and Duncan, 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      hhunspecified

      (Kopp et al., 1997)
      Comments

      Fails to complement the recessive lethality of hh mutant alleles.

      (Kopp et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Muskavitch.

      Comments
      Comments

      Null alleles of bi are epistatic to hhMir.

      (Kopp et al., 1997)

      Ectopic hh expression in the anterior compartment. Three reversions of hhMir have breaks at the hh locus and behave as hh nulls or hypomorphs.

      (Kopp, 1997.5.28)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mir1
      hhMir
      (Wang et al., 2017)
      Name Synonyms
      Mirabile
      (Kopp et al., 1997)
      Secondary FlyBase IDs
      • FBal0012272
      References (6)