FB2024_03 , released June 25, 2024
Allele: Dmel\mirrP1
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General Information
Symbol
Dmel\mirrP1
Species
D. melanogaster
Name
FlyBase ID
FBal0060016
Feature type
allele
Associated gene
Dmel\mirr
Associated Insertion(s)
P{lacW}mirrP1
Carried in Construct
Also Known As
mirr-lacZ, mirror-lacZ
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jordan et al., 1997, McNeill et al., 1997, Broadus et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}mirrP1
Cytology
Description

P{lacW} insertion within 300bp of the beginning of the mirr transcriptional unit.

(McNeill et al., 1997)

P{lacW} insertion in the promoter region of the mirr gene.

(Broadus et al., 1995)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The dorsal appendages become very small and are sometimes lost in embryos derived from mirrP1/TM3 females (this phenotype is not seen in mirrP1/+ females). The denticle belts are normal in these embryos. mirrP1/mirrg14 females lay normal eggs, 100% of which hatch. mirrP1/mirrB1-12 females lay eggs with abnormal eggshells and small dorsal appendages (in 50% of cases), 100% of which hatch.

      (Zhao et al., 2000)

      Clones in the follicle cells result in the loss of appendages and appendage defects.

      (Jordan et al., 1997)

      In 20% of eyes at least one ommatidium close to the equator is misspecified, having ventral chirality and polarity but residing in the dorsal field. 10% eyes display an irregular equator. Homozygotes exhibit abnormal scutellar bristles, dropping halteres, dichaetae wings and missing alulae. Homozygous mothers lay eggs lacking dorsal appendages and often have an open anterior chorion. 30% eggs hatch.

      (McNeill et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision alleles are generated, 3 are lethal, others are viable providing evidence that the P{lacW} insertion is responsible for lethality.

      (Jordan et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mirrF7
      (Tomlinson, 2003)
      mirrP1
      Name Synonyms
      Secondary FlyBase IDs
        References (5)