FB2024_03 , released June 25, 2024
Allele: Dmel\rk11P
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General Information
Symbol
Dmel\rk11P
Species
D. melanogaster
Name
FlyBase ID
FBal0059949
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rkw11p
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P{wAR} insertion in exon 1 of rk.

P{wAR} insertion 4kb upstream of the rk sequence.

P{wAR} insertion at position 9522 of DS01514.

Mutations Mapped to the Genome
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

A significantly increased fraction of border cell clusters in rk11P mosaic egg chambers display migration delay relative to controls. The border cells in rk11P mosaics are properly specified and of the correct number but they often fail to rapidly detach themselves from their epithelial neighbors at the initial stages of migration. Partially mutants border cell clusters fail to cleanly detach themselves from the epithelium more often and display more penetrant delay phenotype than fully mutant clusters, whose behaviour is not significantly different from wild-type clusters. The partially mutant border cell clones also show mislocalization of E-cadherin and apical polarity markers. Neither the detachment phenotype nor the aberrant marker localization is influenced by the presence or absence of rk11P mutant clones also in the anterior follicle cells of the mosaic egg chambers.

Homozygous embryos that are around the time of hatching look like fully developed first instar larvae, with normal segmentation, tracheal trees, mouth hooks and denticle belts and no obvious defects in the gastrointestinal tract.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

R. Levis.

Separable from: a second, lethal mutation. The P{wAR}rk11P insertion is separable from a second mutation on the chromosome that results in embryonic lethality.

Comments
Comments

Excision of the P{wAR} element can revert the mutant phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)