FlyBase Allele Report: Dmel\sim[UAS.cXa]

General Information

Symbol

Dmel\sim^UAS.cXa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Xiao

FlyBase ID

FBal0059939

Feature type

allele

Associated gene

Dmel\sim

Associated Insertion(s)

Carried in Construct

P{UAS-sim.X}

Also Known As

UAS-sim, p[UAS-sim]

Key Links

Transgenic product class

cDNA

(Xiao et al., 1996)

wild_type

(Xiao et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Xiao et al., 1996)

wild_type

(Xiao et al., 1996)

Mutagen

in vitro construct

(Xiao et al., 1996)

Progenitor genotype

Carried in construct

P{UAS-sim.X}

Cytology

Description

UASt regulatory sequences drive expression of a full-length sim cDNA.

(Xiao et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

sim

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^sim.P3.7

(Sedaghat and Sonnenfeld, 2002)

pair rule phenotype, with Scer\GAL4^prd.RG1

(Xiao et al., 1996)

visible, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

Phenotype Manifest In

adult head, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

antenna, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

embryonic/larval cuticle, with Scer\GAL4^prd.RG1

(Xiao et al., 1996)

embryonic brain, with Scer\GAL4^sim.P3.7

(Sedaghat and Sonnenfeld, 2002)

embryonic segment, with Scer\GAL4^prd.RG1

(Xiao et al., 1996)

eye, with Scer\GAL4^ey.PH

(Jiao et al., 2001)

Detailed Description

Statement

Reference

Expression of sim^Scer\UAS.cXa under the control of Scer\GAL4^sim.P3.7 results in the loss of the preoral commissures and reduced postoral commissures in the embryonic brain. The circumesophageal longitudinal connectives are thinner than normal.

(Sedaghat and Sonnenfeld, 2002)

Expression of sim^Scer\UAS.cXa under the control of Scer\GAL4^ey.PH results in a headless phenotype. Three classes of phenotype are seen; class I pharate adults lack all head structures derived from the eye-antennal discs, class II consists of eyeless flies which lack most head structures and both antennae and class III consists of eyeless animals with large parts of the head missing but one or both antennae present.

(Jiao et al., 2001)

Eye morphology is essentially normal in flies expressing sim^Scer\UAS.cXa under the control of Scer\GAL4^GMR.PF.

(Ma et al., 2000)

Scer\GAL4^prd.RG1 mediated expression in wild type embryos causes a pair-rule larval cuticle phenotype. Segmentation defect may result in part from the inability of ectopic midline cells to generate cuticle structures and/or excessive cell death in regions expressing ectopic sim.

(Xiao et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, sim^UAS.cXa has visible phenotype, suppressible | partially by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Jiao et al., 2001)

Scer\GAL4^ey.PH, sim^UAS.cXa has visible phenotype, suppressible | partially by Myc^UAS.cZa, Scer\GAL4^ey.PH

(Jiao et al., 2001)

Enhancer of

Statement

Reference

sim^UAS.cXa, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of D^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2000)

sim^UAS.cXa, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color phenotype of D^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^ey.PH, sim^UAS.cXa has adult head phenotype, suppressible | partially by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Jiao et al., 2001)

Scer\GAL4^ey.PH, sim^UAS.cXa has adult head phenotype, suppressible | partially by Myc^UAS.cZa, Scer\GAL4^ey.PH

(Jiao et al., 2001)

Enhancer of

Statement

Reference

sim^UAS.cXa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of D^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2000)

sim^UAS.cXa, Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle phenotype of D^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2000)

sim^UAS.cXa, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of D^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2000)

sim^UAS.cXa, Scer\GAL4^GMR.PF is an enhancer of pigment cell phenotype of D^UAS.cMa, Scer\GAL4^GMR.PF

(Ma et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Flies expressing both D^Scer\UAS.cMa and sim^Scer\UAS.cXa under the control of Scer\GAL4^GMR.PF show a stronger disorganisation of ommatidia and mechanosensory bristles in the eye than seen in flies expressing either D^Scer\UAS.cMa or sim^Scer\UAS.cXa alone under the control of Scer\GAL4^GMR.PF. There is also a dramatic loss of eye pigmentation in flies expressing both D^Scer\UAS.cMa and sim^Scer\UAS.cXa under the control of Scer\GAL4^GMR.PF.

(Ma et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9581

w^*; P{UAS-sim.X}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sim^Scer\UAS.cXa

sim^UAS.cXa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Xiao

(Xiao et al., 1996)

Secondary FlyBase IDs

References (13)

Report Sections

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