Amino acid replacement: E?K.
Mutation within the fourth laminin G domain.
Nucleotide substitution: G2928A.
G12154795A
G2928A
E885K | Nrx-IV-PA; E885K | Nrx-IV-PB
E?K
Mutant embryos show the presence of septate junctions characterised by discontinuous clusters of septae in the epithelial cells.
Transheterozygotes with Df(3L)vin8 or Df(3L)BK9 are lethal, rare adults escapers are occasionally obtained. Transheterozygotes with Nrx-IV14, Nrx-IV575, Nrx-IV711 and Nrx-IV2511 allow rare adult escapers, adults exhibit rough eyes, notched wings, broadened veins and duplication and malformations of the legs.