FB2024_03 , released June 25, 2024
Allele: Dmel\Nrx-IV46
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General Information
Symbol
Dmel\Nrx-IV46
Species
D. melanogaster
Name
FlyBase ID
FBal0058466
Feature type
allele
Associated gene
Dmel\Nrx-IV
Associated Insertion(s)
Carried in Construct
Also Known As
Nrx46
Key Links
Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Baumgartner et al., 1996)

hypomorphic allele - genetic evidence

(Ward et al., 1998)
Mutagen
ethyl methanesulfonate
(Baumgartner et al., 1996)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nrx-IV46 mutants exhibit a severe dorsal closure phenotype.

      (Schulte et al., 2003)

      Homozygous embryos have dorsal closure defects; dorsal holes are seen in the cuticle. Necrosis is seen in the salivary glands.

      (Ward et al., 1998)

      Transheterozygotes with Df(3L)vin8 or Df(3L)BK9 are lethal, rare adults escapers are occasionally obtained. Transheterozygous embryos with Df(3L)BK9 show a complete absence of muscle-propagation waves; 10% embryonic neuromuscular junctions fail to respond to nerve stimulation and the mean amplitude of evoked synaptic transmission of the remaining junctions is 40%-45% of wild type levels, smooth septate junctions are unaffected, pleated septate junctions lose their characteristic ladder-like septae.

      (Baumgartner et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nrx-IV46
      Nrx46
      (Schulte et al., 2003, Ward et al., 1998, Baumgartner et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)