FB2024_03 , released June 25, 2024
Allele: Dmel\Ubx50.1
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General Information
Symbol
Dmel\Ubx50.1
Species
D. melanogaster
Name
FlyBase ID
FBal0058034
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
P{PZ}Ubx50.1
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Casares et al., 1997)
Mutagen
P-element activity
(Casares et al., 1997)
Progenitor genotype
Ubxbx-Plac61
(Casares et al., 1997)
Associated Insertion(s)
P{PZ}Ubx50.1
Cytology
Description

Deletion preserving the entire P{PZ} element, which lies so that the Ecol\lacZ coding region is transcribed in the same direction as Ubx. The deletion extends from around -27kb to -61kb (coordinates of FBrf0040194), removing the Ubx origin of transcription, 3.5kb of sequences upstream of the initiation site, and 26kb downstream of it, including the positions of the first exon, the two microexons and part of the long intron. It extends to the position where the bithorax mutations map.

(Casares et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ubx50.1/Ubxbx-3 flies show only a thin transformed metanotum and their halteres show a much milder transformation than that of Ubx1/Ubxbx-3 flies. UbxI.7/Ubxbx-3 flies show a stronger transformation, despite the similarity of the molecular lesions in Ubx50.1 and UbxI.7. Ubx50.1/Ubxpbx-1 and UbxI.7/Ubxpbx-1 flies show a milder phenotype in the haltere than Ubx1/Ubxpbx-1 or Ubxpbx-1/Df(3R)P9, indicating there is transvection.

      (Casares et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ubx50.1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)