FB2024_03 , released June 25, 2024
Allele: Dmel\btlKR.hs
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General Information
Symbol
Dmel\btlKR.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0057722
Feature type
allele
Associated gene
Dmel\btl
Associated Insertion(s)
Carried in Construct
P{hs-btlK->R}
Key Links
Transgenic product class
missense_variant
(Lee et al., 1996)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Lee et al., 1996)
Mutagen
in vitro construct
(Lee et al., 1996)
Progenitor genotype
btlhs.PM
(Lee et al., 1996)
Carried in construct
P{hs-btlK->R}
Cytology
Description

Mutation of the conserved Lys residue within the ATP binding domain to Arg.

(Lee et al., 1996)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
btl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fewer proliferating air sac tracheoblasts are seen in third instar wing discs of btlKR.hs larvae after heat shock than in wild type controls. Within 3-5 hours of a brief heat shock in btlKR.hs larvae, air sac tracheoblasts of the wing disc exhibit loss of the numerous filopodia that they exhibit in the wild-type. 24 hours after heat shock, these cells produce filopodia as normal.

      (Sato and Kornberg, 2002)

      Heat induced expression in wild type stage 11 embryos causes defects in tracheal primary branching. Induced expression at stage 12 does not affect primary branching but formation of secondary branches is inhibited. Heat induced coexpression of btlKR.hs and btlhs.T:λ\cI-DD at stage 11 almost completely blocks primary branching and coexpression at stage 12 rescues the secondary branching defects.

      (Lee et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      btlKR.hs is partially rescued by btlλ.hs

      (Lee et al., 1996)
      Comments

      Heat induced coexpression of btlKR.hs and btlhs.T:λ\cI-DD at stage 11 almost completely blocks primary branching and coexpression at stage 12 rescues the secondary branching defects of btlKR.hs embryos.

      (Lee et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      btlKR.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (2)