FB2024_03 , released June 25, 2024
Allele: Dmel\lblhs.PJ
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General Information
Symbol
Dmel\lblhs.PJ
Species
D. melanogaster
Name
heat shock construct of Jagla
FlyBase ID
FBal0056539
Feature type
allele
Associated gene
Dmel\lbl
Associated Insertion(s)
Carried in Construct
P{hs-lbl}
Key Links
Transgenic product class
cDNA
(Jagla et al., 1997)
wild_type
(Jagla et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Jagla et al., 1997)
wild_type
(Jagla et al., 1997)
Mutagen
in vitro construct
(Jagla et al., 1998, Jagla et al., 1997, Jagla et al., 1997)
Progenitor genotype
Carried in construct
P{hs-lbl}
Cytology
Description

Full length cDNA is expressed from a heat inducible promoter.

(Jagla et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
lbl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Coexpression of P{hs-lbe} and P{hs-lbl} by triple heat-shock treatments (15 minutes each) between 4 and 9 hours AEL causes strong abnormalities in the dorsal denticle pattern of wild-type embryos.

      (Jagla et al., 1997)

      Overexpression of lblhs.PJ at 5-6 hours AEL leads to a significant hyperplasia of heart progenitor cells.

      (Jagla et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When lbehs.PJ and lblhs.PJ are co-expressed in embryos (by heatshock induction) gaps in somatic musculature are seen associated with a significantly enlarged heart area.

      (Jagla et al., 2002)

      Embryos expressing both lbehs.PJ and lblhs.PJ at 5 hours after egg laying (using heat shock) contain supernumerary myoblasts which fuse to form enlarged segmental border muscles in approximately 70% of hemisegments.

      (Jagla et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      lblhs.PJ
      Name Synonyms
      heat shock construct of Jagla
      (Jagla et al., 1997)
      Secondary FlyBase IDs
        References (4)