FB2024_03 , released June 25, 2024
Allele: Dmel\wdn48
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General Information
Symbol
Dmel\wdn48
Species
D. melanogaster
Name
FlyBase ID
FBal0050820
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Imprecise excision of a P-element which has deleted wdn sequence from -715bp to +898bp. This removes 700bp of 5' flanking sequence, the transcription start site, the translation start site and the first quarter of the coding sequence.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

1613bp deletion resulting from the imprecise excision of a P element that is reported to extend from -715bp to +898bp relative to the wdn transcription start site. 3R:28811338 was used as the transcription start site (FBrf0048671).

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous flies have a number of defects; young flies generally hold their wings at approximately 45o above horizontal, whereas older flies (and occasionally young flies) have drooping wings that prevent the fly from walking normally. The anterior cross vein is often either deformed or eliminated by increased proximity of veins L3 and L4. The posterior cross vein is often interrupted, with the anterior part is missing. Some of the macrochaetae, most frequently the scutellar, postalar and dorsocentral, may be duplicated or triplicated, with 2-6 extra bristles per fly. This extra bristle phenotype is stronger in females than males. Homozygous females give no viable progeny, whatever the genotype of the male they are mated to. Approximately 75% of the eggs laid by these females appear to be unfertilised and undergo no nuclear division. Approximately 25% undergo nuclear cleavages and cellularise. Morphological movements leading to gastrulation and germ-band extension are severely disrupted. In all cases these animals die as embryos. 1-3% of the embryos do not show developmental alterations before or during gastrulation and germ-band extension, but die as morphologically normal prehatching embryos or first or second instar larvae.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)