FB2024_03 , released June 25, 2024
Allele: Dmel\lzr15
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General Information
Symbol
Dmel\lzr15
Species
D. melanogaster
Name
FlyBase ID
FBal0050117
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description

Imprecise excision of the P-element of lzSprite.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemolymph from mutant larvae produces longer fibres than those from control larvae in a drawout assay testing coagulation.

Homozygous larvae are completely devoid of visible crystal cells.

There are no cone cells present in lzr15 larval or pupal eyes.

Homozygous or hemizygous mutant animals fail to form a normal scab after wounding - a diffuse plug at the wound site is seen instead of the consolidated plug and scab that are normally present 24h after wounding. Only about 15% of mutant larvae survive a normal puncture wound procedure, most of whom are sluggish and flaccid: 85% of wild-type larvae survive this procedure. Most of the cellular responses to wounding appear to initiate in mutant larvae, although they do not progress normally. Epidermal cell fusion occurs, but the syncytium often occupies a greater area than in control larvae. The surrounding epidermal cells also appear to organise around the wound, but their cell borders are slack and wavy, even several cell diameters out from the wound. These epidermal cells can be separated from the overlying cuticle around the wound. Sometimes the edges of the punctured epidermis meet to restore epithelial integrity, but in most cases they do not. Crystal cells are not seen in mutant larvae.

Plamatocytes develop normally in number and pattern.

Eye colour: white. Eyes of mutant flies are shiny compared to controls. The ocelli appear reasonably normal under low power SEM. The eyes have corneal nipples which look much like those of control flies under high power SEM except with more irregularities.

Adult eye has a smooth surface lacking lenses and the ommatidial array. Partial or complete loss of tarsal claws in the leg, a reduction of the third antennal segment and partial loss of female fertility.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (11)