FB2024_03 , released June 25, 2024
Allele: Dmel\Dhc64C3-2
Open Close
General Information
Symbol
Dmel\Dhc64C3-2
Species
D. melanogaster
Name
FlyBase ID
FBal0048182
Feature type
allele
Associated gene
Dmel\Dhc64C
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gepner et al., 1996)
Mutagen
ethyl methanesulfonate
(Gepner et al., 1996)
Progenitor genotype
Cytology
Description

Genomic Southern blotting revealed no polymorphism between the mutant and wild type chromosome.

(Gepner et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In the cysts of Dhc64C6-12/Dhc64C3-2 females, there are some fusome structures but these are fragmented and do not extend into all cells of the cyst. Additionally, the number of cyst divisions are reduced, resulting in egg chambers that contain fewer than 16 cells. The mitotic synchrony of these divisions is as wild type.

      (Snapp et al., 2004)

      Dhc64C3-2/Dhc64C6-12 transheterozygous ovaries do not produce mature eggs; the egg chambers do not contain a developing oocyte and each cell develops with a polyploid nucleus like a nurse cell. Fusomes are present in the germ line cysts but they appear less branched than wild type. Normal fusome morphology is rescued with Dhc64C+tDN17. The mitotic spindles appear randomly oriented within the cyst and frequently fail to become attached to one branch of the fusome.

      (McGrail and Hays, 1997)

      Lethality acts before or during larval stages. Low levels (3-12%) of embryonic lethality are observed.

      (Gepner et al., 1996)

      Dhc64C3-2/Dhc64C6-10 flies show disruptions in the shape, size and organisation of the ommatidia.

      (McGrail et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements Dhc64C8-1. Intragenic complementation relationships involve Dhc64C5-6, Dhc64C6-6, Dhc64C6-8, Dhc64C6-10, Dhc64C6-12 and Dhc64C8-1.

      (Gepner et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dhc64C3-2
      dhc64c3-2
      (Li et al., 2023)
      l(3)64Ca3-2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)