FB2024_03 , released June 25, 2024
Allele: Dmel\CycAΔ.Tag:HA
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General Information
Symbol
Dmel\CycAΔ.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0048163
Feature type
allele
Associated gene
Dmel\CycA
Associated Insertion(s)
Carried in Construct
P{Hs-ΔcyclinA}
Key Links
Transgenic product class
inframe_deletion
(Sigrist et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Sigrist et al., 1995)
Mutagen
in vitro construct
(Sigrist et al., 1995)
Progenitor genotype
CycAhs.PK
(Sigrist et al., 1995)
Carried in construct
P{Hs-ΔcyclinA}
Cytology
Description

The sequence between the NcoI site at position 295 to the EcoRV site at position 804, amino acids 1 to 171, (including the destruction box) is replaced by the Tag:HA epitope.

(Sigrist et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
CycA
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      egg chamber & cell

      (Lilly et al., 2000)

      egg chamber & mitotic cell cycle

      (Lilly et al., 2000)

      nurse cell fusome

      (Lilly et al., 2000)
      Detailed Description
      Statement
      Reference

      Expression of homozygous CycAΔ.T:Ivir\HA1 at the permissive temperature prevents or severely delays cell cycle progression at metaphase.

      (Baldinger and Gossen, 2009)

      When CycAΔ.T:Ivir\HA1 is over-expressed in adult females germline cysts with an aberrant number of cells are produced. Five days after heat-shock treatment cysts containing 32 instead of 16 cells are seen in 17% of egg chambers. The oocyte contains 5 ring canals (as compared to 4 in wild-type). Very rarely, cysts with an intermediate number of cells (in between 16 and 32) are seen. Abnormally large fusomes are also seen.

      (Lilly et al., 2000)

      Expression delays cell cycle progression after entry into mitosis, predominantly metaphase figures are seen.

      (Sigrist et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      CycAΔ.Tag:HA has phenotype, suppressible by bamΔ86

      (Lilly et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CycAΔ.T:HA1
      CycAΔ.T:Ivir\HA1
      CycAΔ.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)