FlyBase Allele Report: Dmel\en[Apa]

General Information

Symbol

Dmel\en^Apa

Species

D. melanogaster

Name

FlyBase ID

FBal0048012

Feature type

allele

Associated gene

Dmel\en

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Kopp et al., 1999, Kopp et al., 1997)

Mutagen

Progenitor genotype

Cytology

Description

Rearrangement breakpoint in en.

(Kopp et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Kopp and Duncan, 2002, Kopp et al., 1997)

Phenotype Manifest In

abdominal tergite & macrochaeta

(Kopp et al., 1997)

abdominal tergite & trichome

(Kopp et al., 1997)

tergite

(Kopp and Duncan, 2002, Kopp et al., 1997)

tergite anterior compartment

(Kopp and Duncan, 2002)

tergite posterior compartment | ectopic

(Kopp and Duncan, 2002)

Detailed Description

Statement

Reference

Much of the tergite is transformed to symmetrically patterned posterior hairy zone (PHZ) and intersegmental membrane in heterozygotes (transformation of anterior compartment to posterior compartment structures). Abdominal segment 1 is almost unaffected.

(Kopp and Duncan, 2002)

Each abdominal segment consists mostly of a broad central region of posterior hairy zone (PHZ) cuticle flanked to the anterior and posterior by intersegmental membrane (ISM) in heterozygous flies. Each abdominal segment is mirror symmetric, with the PHZ trichomes in the anterior half of the segment directed anteriorly, and the trichomes in the posterior half of the segment directed posteriorly. Interspersed islands of apparently normal abdominal cuticle with normal polarity are seen. The patches of tergite cuticle are lightly pigmented and do not carry macrochaetae. en^Es/en^Apa transheterozygotes have a similar phenotype, except that no tergite islands are present.

(Kopp et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

en^Apa has phenotype, non-suppressible by hh^αTub84B.PB

(Kopp and Duncan, 2002)

en^Apa has phenotype, non-suppressible by hh^UAS.cPb/Scer\GAL4^Act5C.PP

(Kopp and Duncan, 2002)

en^Apa has phenotype, non-suppressible by smo³

(Kopp and Duncan, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

smo³ homozygous clones generated in an en^Apa/+ background have no effect on cell fate or polarity in the tergites; smo³ mutant cells located posterior to the line of symmetry retain posterior orientation, while smo³ mutant cells located anterior to the line retain anterior orientation. The smo³ clones interdigitate freely with the surrounding cells. Expression of hh^Scer\UAS.cPb in clones under the control of Scer\GAL4^Act5C.PP has no effect on cell fate or polarity in the abdominal tergites in en^Apa/+ adults. Expression of hh^αTub84B.PB in clones has no effect on cell fate or polarity in the abdominal tergites in en^Apa/+ adults.