FB2024_03 , released June 25, 2024
Allele: Dmel\Sxlf10,M1
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General Information
Symbol
Dmel\Sxlf10,M1
Species
D. melanogaster
Name
FlyBase ID
FBal0045175
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Bernstein et al., 1995)
Mutagen
gamma ray
(Maine et al., 1985)
Progenitor genotype
SxlM1
(Bernstein et al., 1995, Maine et al., 1985)
Cytology
Description

Frameshift terminating translation after 14 scrambled residues. Frameshift deletes an A in exon 6; in the sixth residue of putative beta sheet 3 in RRM#1.

(Bernstein et al., 1995)

No gross alteration in the DNA. Original SxlM1 mutation is intact.

(Maine et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:7,085,486..7,085,486 [-]
Comment:

Deletion of A base in the sixth amino acid of the putative beta sheet 3 of RRM1 (structure according to FBrf0089950) leads to a frameshift and translation termination after 14 additional amino acids.

(Bernstein et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Null for all somatic and germline functions.

      (Bernstein et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sxlf10,M1
      (Pal Bhadra et al., 2006)
      Sxlfm4,M1
      Sxlfm4
      (Maine et al., 1985)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)