FB2024_03 , released June 25, 2024
Allele: Dmel\knitRa
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General Information
Symbol
Dmel\knitRa
Species
D. melanogaster
Name
FlyBase ID
FBal0043140
Feature type
allele
Associated gene
Dmel\kni
Associated Insertion(s)
Carried in Construct
P{kniSH}
Also Known As
kni-transgene
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Rothe et al., 1992)
wild_type
(Rothe et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Rothe et al., 1992)
wild_type
(Rothe et al., 1992)
Mutagen
in vitro construct
(Lunde et al., 1998, Pankratz et al., 1992, Rothe et al., 1992)
Progenitor genotype
Carried in construct
P{kniSH}
Cytology
Description

9.5kb SalI/HindIII fragment containing about 5.5kb of upstream sequences, the complete kni transcription unit (3 kb) and about 1kb of downstream sequences.

(Nauber, 1999.8.30)

kni upstream sequences, including the 5' end of the transcription unit and extending over 5kb upstream of the transcription unit drive kni expression.

(Lunde et al., 1998)

Fragment that contains the kni coding region and 6kb of flanking sequences.

(Pankratz et al., 1992)

9.5kb genomic SalI-HindIII fragment including kni transcription unit and 6.5kb of flanking sequences.

(Rothe et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
kni
kni_rescue_SH
Encoded product / tool
kni
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:20,691,556..20,701,094 [-]
Linked to:
SalI-HindIII restriction fragment
Comment:

Fragment rescues the kni mutant abdominal segment pattern and weakly rescues the head defects.

(Rothe et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The tracheal systems of knitRa; Df(3L)ri-XT1/+ embryos lack dorsal branches, but small 'trunk-like' buds are sometimes seen in their place.

      (Ribeiro et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      knitRa rescues kniunspecified

      (Pankratz et al., 1992)
      Partially rescues

      knitRa partially rescues kni8

      (Chen et al., 1998)

      knitRa partially rescues Df(3L)ri-XT1

      (Gonzalez-Gaitan et al., 1994)

      knitRa partially rescues kni8

      (Rothe et al., 1992)
      Comments

      Rescues the segmentation and tracheal phenotype of kni8.

      (Chen et al., 1998)

      Fails to rescue the "ri" phenotype.

      (Lunde et al., 1998)

      Expression of knitRa construct leads to the development of the SNS in Df(3L)ri-XT1 embryos.

      (Gonzalez-Gaitan et al., 1994)

      Mutant abdominal phenotype of kni8 and Df(3L)ri-XT1 embryos can be rescued by knitRa but head defects are incompletely rescued.

      (Rothe et al., 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      knicLa
      knitRa
      Name Synonyms
      kni-transgene
      (Ribeiro et al., 2002)
      Secondary FlyBase IDs
      • FBal0034819
      • FBal0092910
      References (10)