FlyBase Allele Report: Dmel\inv[W]

General Information

Symbol

Dmel\inv^W

Species

D. melanogaster

Name

wingless

FlyBase ID

FBal0043136

Feature type

allele

Associated gene

Dmel\inv

Associated Insertion(s)

Carried in Construct

Also Known As

Inv^D

Key Links

Allele class

heat sensitive gain of function allele

Mutagen

X ray

Nature of the Allele

Allele class

heat sensitive gain of function allele

(Simmonds and Bell, 1998)

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(2R)vg^W

Cytology

Description

vg enhancers influence inv expression.

(Simmonds and Bell, 1998)

inv coding sequences are under the control of vg enhancer elements.

(Simmonds et al., 1995)

Inversion breakpoint approximately 8kb upstream of the inv transcription start site. This results in a fusion between the centromere distal part of vg and the inv region.

(Williams et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Williams et al., 1991, Williams and Bell, 1988)

visible | dominant | homeotic | heat sensitive

(Simmonds and Bell, 1998)

Phenotype Manifest In

anterior-posterior compartment boundary of the wing blade

(Simmonds and Bell, 1998)

wing | anterior

(Simmonds and Bell, 1998)

wing vein

(Simmonds and Bell, 1998)

wing vein L1

(Simmonds et al., 1995)

wing vein L2

(Simmonds et al., 1995)

Detailed Description

Statement

Reference

Heterozygotes have a mirror image homeotic transformation of anterior wing to posterior wing. All anterior wing blade structures are replaced with a mirror image of the posterior structures. No transformation of the wing hinge, notum or pleural thoracic tissue is seen. The transformation phenotype is weakest at lower temperatures. inv^W/inv^unspecified flies have a similar phenotype to inv^W/+ heterozygotes, although the wing veins adjacent to the anterior/posterior compartment border are often incomplete at the distal tip of the wing.

(Simmonds and Bell, 1998)

Anterior to posterior cell fate transformation in the wing, veins 1 and 2 are replaced by 4 and 5 with the associated crossvein.

(Simmonds et al., 1995)

One dose removes entire wing margin.

(Williams and Bell, 1988)

homozygous lethal; dominant with homeotic effect; vg^W/+ is wingless or has tiny buds, no halteres (or one); female fertile and viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

inv^W has visible | dominant phenotype, suppressible by ph-d²⁰⁹/ph-d[+]

(Simmonds and Bell, 1998)

Other

Statement

Reference

Df(2R)en-SFX31, inv^W has visible | dominant phenotype

(Simmonds and Bell, 1998)

Phenotype Manifest In

Suppressed by

Statement

Reference

inv^W has wing vein phenotype, suppressible by ph-d²⁰⁹/ph-d[+]

(Simmonds and Bell, 1998)

Other

Statement

Reference

Pc¹⁶, inv^W has wing phenotype

(Randsholt et al., 2000)

Psc¹, inv^W has wing phenotype

(Randsholt et al., 2000)

Df(2R)en-SFX31, inv^W has wing phenotype

(Simmonds and Bell, 1998)

Df(2R)en-SFX31, inv^W has wing vein phenotype

(Simmonds and Bell, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

inv^W/Psc¹ wings and inv^W/+;Pc¹⁶/+ wings exhibit a wing phenotype (similar to the gain of function ci phenotype).

(Randsholt et al., 2000)

Wing vein formation is suppressed in inv^W ph-d²⁰⁹ double heterozygotes both within the normal and transformed portions of the wing. inv^W/Df(2R)en-SFX31 flies show the transformation of anterior compartment to posterior compartment and disorganisation of wing veins. Wings are held out and down.

(Simmonds and Bell, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1573

In(2R)vg^W, vg^W inv^W/In(2L)Cy, In(2R)Cy, Duox^Cy amos^Roi-1 cn² bw¹ or¹ speck²

Kyoto

106394

In(2R)vg^W, vg^W inv^W/In(2L)Cy, In(2R)Cy, amos^Roi-1 cn² bw¹ or¹ speck²

Notes on Origin

Discoverer

Shukla.

Comments

The inv^W homeotic wing phenotype is difficult to study using this chromosome because In(2R)vg^W also causes a dominant vg^W allele which produces a loss of wing phenotype. γ ray mutagenesis of the In(2R)vg^W chromosome resulted in a deletion which altered the vg^W mutation to a recessive vg allele (vg^WR2). This allows the dominant inv^W phenotype to be studied.

(Simmonds and Bell, 1998)

It is difficult to determine inv activity in In(2R)vg^W, but the possibility that inv^W has a neomorphic contribution to the vg^W phenotype cannot be eliminated.

(Williams et al., 1990)

inv is expressed in a vg-like pattern.

(Simmonds and Bell, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Inv^D

(Gibert et al., 2002)

inv^D

(Randsholt et al., 2000, Simmonds and Bell, 1998)

inv^W

vg^WRK2

(Simmonds and Bell, 1995)

Name Synonyms

wingless

Secondary FlyBase IDs

FBal0034814

References (13)

Report Sections

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