FlyBase Allele Report: Dmel\barr[k14014]

(Chen et al., 2008, Butler et al., 2001, Xu et al., 2001, Liu et al., 1999, Spradling et al., 1999, Bhat et al., 1996, Kania et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Liu et al., 1999, Bhat et al., 1996, Kania et al., 1995)

some die during embryonic stage | recessive

(Liu et al., 1999, Bhat et al., 1996, Kania et al., 1995)

Phenotype Manifest In

Detailed Description

Statement

Reference

Average Citrate Synthase activity is increased by 9% in heterozygous males

(Chen et al., 2008)

Malpighian tubules are not fully elongated in mutant embryos. Proventriculus morphogenesis and invagination of the pharynx are incomplete. Midgut constrictions do not form. Head involution is incomplete, tracheae are abnormal and there are holes in the epidermis.

(Liu et al., 1999)

Homozygous embryos exhibit severe loss of PNS neurons and a significant increase in size of remaining neurons. Embryos arrest in cycle 16.

(Bhat et al., 1996)

Homozygous embryos exhibit pathfinding and organisation defects.

(Kania et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

barr^k08103

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11117

y¹ w^67c23; P{lacW}barr^k14014/CyO

Kyoto

111336

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{lacW}barr^k14014 P{neoFRT}40A/CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

Comments

Precise excision of the P{lacW} element reverts the lethal phenotype.

(Xu et al., 2001)

Complements: neb⁰³⁵⁵². Complements: neb⁰⁵²¹⁷. Complements: l(2)k10239^k10239. Complements: l(2)k11537^k11537. Complements: neb^s4158.

(BDGP Project Members, 1994-1999)

P{lacW} insertion can be excised and the revert the lethal phenotype to wild type. barr^k14014 and barr^k14028 insertions may be members of the same cluster and not genuine alleles. Phenotypic analysis provides an allelic series: neb^k00802 < barr^k14014 < barr^k14028 < barr^k00310 < barr^k13903 < barr^k04805 < barr^k04912.

(Kania et al., 1995)

P{lacW} insertion is revertible.

(Bhat et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

140/14

(Kania et al., 1995)

P140/14

(Bhat et al., 1996)

barr^K14014

(Chen et al., 2008)

barr^k14014

k14014

(Liu et al., 1999)

l(2)k14014

(Butler et al., 2001, Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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