FB2024_03 , released June 25, 2024
Allele: Ecol\lacZUbx.bxd14.5
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General Information
Symbol
Ecol\lacZUbx.bxd14.5
Species
E. coli
Name
FlyBase ID
FBal0042161
Feature type
allele
Associated gene
Ecol\lacZ
Associated Insertion(s)
Carried in Construct
P{bxd14.5}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hodgson et al., 1997, Chang et al., 1995, Chiang et al., 1995, Simon et al., 1993, Simon et al., 1990)
Progenitor genotype
Ecol\lacZUbx.P140
(Chang et al., 1995, Chiang et al., 1995, Simon et al., 1990)
Carried in construct
P{bxd14.5}
Cytology
Description

14.5kb DNA containing the region -13.5 and -28kb relative to the Ubx transcription start site regulates expression of lacZ.

(Chinwalla et al., 1995)

A 14.5kb fragment of bxd regulatory region of Ubx (coordinates -18.5kb to -4kb on the BX-C walk) is fused upstream of Ecol\lacZUbx.P140.

(Simon et al., 1990)
Allele components
Component
Use(s)
Encoded product / tool
lacZ
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 11
      embryonic/larval muscle system
      (Simon et al., 1990)
      presumptive embryonic/larval central nervous system
      (Simon et al., 1990)
      embryonic epidermis
      (Simon et al., 1990)
      embryonic stage 12
      parasegment 6 -- parasegment 13
      (Simon et al., 1993)
      embryonic stage 15
      parasegment 6
      (Simon et al., 1990)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Ubx
      (Simon et al., 1993, Simon et al., 1990)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer

      Simon

      (Chiang et al., 1995)
      Comments
      Comments

      Presence of trx is able to maintain long term Ubx expression.

      (Chinwalla et al., 1995)

      Carried in plasmid "Ubx-B", expressed in haploid cell line 1182-4 and the effect of trx and Pc on the Ubx promoter is studied to determine if trx is involved in promoter activation and Pc-dependent repression can be reproduced. Competitive interactions between trx and Pc are also examined in haploid cell line 1182-4 using Ecol\lacZUbx.bxd14.5.

      (Chang et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Ecol\lacZUbx.bxd14.5
      bxd-14
      (Hodgson et al., 1997)
      lacZUbx.bxd14.5
      lacZUbx.bxd14
      (Simon et al., 1993)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)