FB2024_03 , released June 25, 2024
Allele: Dmel\per+t7.2
Open Close
General Information
Symbol
Dmel\per+t7.2
Species
D. melanogaster
Name
FlyBase ID
FBal0039741
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{perC7.2}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Cooper et al., 1994, Frisch et al., 1994, Hardin et al., 1990)
Progenitor genotype
Carried in construct
P{perC7.2}
Cytology
Description

Consists of a truncated per gene in which the promoter and a portion of the first (non-coding) exon are deleted.

(Krishnan et al., 1999)

7.2kb per DNA, 5' end begins within the first intron so contains all coding regions and 3' flanking sequence. 5' end is 800bp closer to the second intron than per+t14.6 or per+t8.0.

(Cooper et al., 1994)

Promoterless 7.2kb genomic fragment of per.

(Frisch et al., 1994)

7.2kb fragment that contains all the per coding DNA, but is missing much of the non-coding DNA, including exon 1.

(Hardin et al., 1990)
Allele components
Component
Use(s)
Encoded product / tool
per
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rescue circadian behavioural rhythms of per01 flies. Exhibit free-running, temperature-compensated behavioural rhythms and can also entrain and re-entrain to LD cycles.

      (Frisch et al., 1994)

      Long cycle duration, the evening peak of activity is shifted to a later time than wild type.

      (Hamblen-Coyle et al., 1992)

      per01 flies transformed with this allele are frequently rhythmic, though circadian periods are slightly longer than the normal range.

      (Yu et al., 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      per+t7.2 rescues per01

      (Donlea et al., 2009)

      per+t7.2 rescues per01

      (Mazzoni et al., 2005)

      per+t7.2 rescues per01

      (Cooper et al., 1994)

      per+t7.2 rescues per01

      (Frisch et al., 1994)
      Partially rescues

      per+t7.2 partially rescues per01

      (Beaver and Giebultowicz, 2004)
      Fails to rescue

      per+t7.2 fails to rescue per01

      (Fujii et al., 2007)

      per+t7.2 fails to rescue per01

      (Krishnan et al., 1999)
      Comments

      per01; per+t7.2 flies display normal experience-dependent increase in sleep. per01; per+t7.2 flies display long-term memory and increase in sleep.

      (Donlea et al., 2009)

      The pronounced circadian rhythm of close-proximity encounters seen in wild-type male:female pairs is lost when the male is hemizygous for per01. This phenotype is not rescued by P{perC7.2}2.

      (Fujii et al., 2007)

      The blindness of per01 mutants at 750 lux is rescued by the presence of per+t7.2, whose expression is limited to the LNs.

      (Mazzoni et al., 2005)

      The extension of time spent copulating seen in per01 hemizygous males mated with wild type females is not suppressed by per+t7.2, even though it does rescue rhythmic locomoter activity in these flies.

      (Beaver and Giebultowicz, 2004)

      Circadian rhythms in olfactory responses to ethyl acetate are abolished in per01 mutants that also have the P{perC7.2} transgene.

      (Krishnan et al., 1999)

      Rescues the arrhythmicity of per01 flies.

      (Cooper et al., 1994)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      per expression, with respect to behavioural circadian rhythms, is dosage compensated.

      (Cooper et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      per+t7.2
      Name Synonyms
      Secondary FlyBase IDs
        References (14)