FB2024_03 , released June 25, 2024
Allele: Dmel\dhdP8
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General Information
Symbol
Dmel\dhdP8
Species
D. melanogaster
Name
FlyBase ID
FBal0039240
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

P{lacW} insertion within the dhd coding sequence.

P{lacW} insertion in the open reading frame at the 5' end of the gene.

Allele components
Component
Use(s)
Inserted element
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Female sterile over Df(1)DEB4D. Eggs from mutant mothers fail to complete meiosis. In 90% of embryos there is no sign of development and no evidence of a female pronucleus. Normal polar body structures are only rarely observed. Most common phenotype is that eggs contain a structure that resembles a nucleus arrested in anaphase. In the 10% of embryos that initiate development, there are defects in preblastoderm nuclear divisions. Divisions are not synchronous. Not all nuclei migrate to the periphery. 5% of embryos develop far enough to secret cuticle. Head involution fails during gastrulation. In embryos where head involution is partial, the most prominent defects are shortening of the lateralgraten and fusion of the ventral arms of the cephalopharyngeal skeleton.

External Data
Interactions
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Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The reduction in climbing ability seen in 50 day old flies expressing Hsap\GPR37Scer\UAS.cYa under the control of Scer\GAL4elav.PLu is made more severe by the addition of dhdP8/+.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Light yellow eyes due to P{lacW} insertion.

Mutant phenotype is not rescuable by paternally contributed wild type allele. Δ2-3-induced revertants have lost the P{lacW} insertion.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)