FlyBase Allele Report: Dmel\sqd[K12]

General Information

Symbol

Dmel\sqd^K12

Species

D. melanogaster

Name

FlyBase ID

FBal0035700

Feature type

allele

Associated gene

Dmel\sqd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kelley, 1993)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | maternal effect

(Roth and Schupbach, 1994)

some die during embryonic stage | maternal effect

(Roth and Schupbach, 1994)

Phenotype Manifest In

dorsal appendage (with sqd¹)

(Goodrich et al., 2004)

dorsal appendage | maternal effect

(Roth and Schupbach, 1994)

egg (with sqd¹)

(Goodrich et al., 2004)

egg chorion (with sqd¹)

(Goodrich et al., 2004)

egg chorion | dorsal

(Kelley, 1993)

egg operculum (with sqd¹)

(Goodrich et al., 2004)

filzkorper | maternal effect

(Roth and Schupbach, 1994)

Detailed Description

Statement

Reference

Of the eggs laid by sqd¹/sqd^K12 transheterozygotes, around 50 % exhibit some degree of dorsalisation: the least affected have widely spaced dorsal appendage and an enlarged operculum; intermediately affected have a single broad appendage that spans at least the width of the normal appendages; severely affected (<5%) have a crown of appendage material that surrounds the anterior circumference of the egg. Nurse cell chromosome morphology is normal in sqd^K12 homozygotes.

(Goodrich et al., 2004)

Weak dorsalization of egg shell. Dorsal appendages are enlarged in 46% of eggs and ventrally fused in 54% of eggs. 9% of eggs contain embryos, which are dorsalized anteriorly and in half the cases have reduced filzkorper indicating weak posteriorly ventralization.

(Roth and Schupbach, 1994)

Embryos laid by hemizygous mothers are partially dorsalised. Heterozygotes with sqd¹ are wild type with only a few dorsalised embryos.

(Kelley, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

sqd¹/sqd^K12 has egg chorion phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203

(Goodrich et al., 2004)

sqd¹/sqd^K12 has dorsal appendage phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg operculum phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k10413

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k10413

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg operculum phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg chorion phenotype, enhanceable by Hrb27C³⁷⁷/Hrb27C⁰²⁶⁴⁷

(Goodrich et al., 2004)

sqd¹/sqd^K12 has dorsal appendage phenotype, enhanceable by Hrb27C³⁷⁷/Hrb27C⁰²⁶⁴⁷

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg operculum phenotype, enhanceable by Hrb27C³⁷⁷/Hrb27C⁰²⁶⁴⁷

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg phenotype, enhanceable by Hrb27C³⁷⁷/Hrb27C⁰²⁶⁴⁷

(Goodrich et al., 2004)

sqd¹/sqd^K12 has egg chorion phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k10413

(Goodrich et al., 2004)

sqd¹/sqd^K12 has dorsal appendage phenotype, enhanceable by Hrb27C¹⁰²⁸⁰/Hrb27C^k10413

(Goodrich et al., 2004)

Other

Statement

Reference

Hrb27C¹⁰²⁸⁰/Hrb27C^k16203, sqd¹/sqd^K12 has nurse cell & nuclear chromosome phenotype

(Goodrich et al., 2004)

Hrb27C¹⁰²⁸⁰/Hrb27C^k10413, sqd¹/sqd^K12 has nurse cell & nuclear chromosome phenotype

(Goodrich et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Dorsalisation of the eggs laid by sqd¹/sqd^K12 transheterozygotes is enhanced by Hrb27C¹⁰²⁸⁰/Hrb27C^k16203, so that >98% show some degree of dorsalisation, and by Hrb27C¹⁰²⁸⁰/Hrb27C^k10413, so that 100% show some degree of dorsalisation. In sqd¹/sqd^K12; Hrb27C¹⁰²⁸⁰/Hrb27C^k10413 and sqd¹/sqd^K12; Hrb27C¹⁰²⁸⁰/Hrb27C^k16203 females, nurse cell chromosomes fail to disperse after stage 6, but instead arrest in the blob like conformation typical at stage 6 of oogenesis.

(Goodrich et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

sqd^K12

(Olesnicky et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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