FlyBase Allele Report: Dmel\rux[9]

General Information

Symbol

Dmel\rux⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0035526

Feature type

allele

Associated gene

Dmel\rux

Associated Insertion(s)

P{lacW}rux⁹

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Gonczy et al., 1994)

Mutagen

P-element activity

(Gonczy et al., 1994)

Progenitor genotype

Associated Insertion(s)

P{lacW}rux⁹

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cytokinesis | recessive

(Gonczy et al., 1994)

abnormal meiotic cell cycle

(Gonczy et al., 1994)

male sterile

(Gonczy et al., 1994)

visible | recessive

(Gonczy et al., 1994)

Phenotype Manifest In

cyst cell of testis

(Gonczy et al., 1994)

eye

(Gonczy et al., 1994)

Nebenkern

(Gonczy et al., 1994)

onion stage spermatid

(Gonczy et al., 1994)

Detailed Description

Statement

Reference

Severe roughened eye phenotype. Sterile in males. The majority of onion stage cysts appear normal with 64 cells, with nuclei with decondensed chromatin and nebenkern of similar size. However these cells go on to attempt an extra division after meiosis II, sometimes assembling a monopolar spindle, resulting in cells with variable number and size of nuclei. Some cells attempt an extra cytokinesis. The extra division is not preceded by an extra S phase, nor by duplication of the centrioles. No normal germ cells were found in later stage rux cysts. Semisterile in females.

(Gonczy et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

rux⁹ has phenotype, non-enhanceable by stg⁴

(Gonczy et al., 1994)

rux⁹ has phenotype, non-enhanceable by Cdk1^unspecified

(Gonczy et al., 1994)

Suppressed by

Statement

Reference

rux⁹ has phenotype, suppressible by CycA⁵

(Gonczy et al., 1994)

rux⁹ has phenotype, suppressible by twe¹

(Gonczy et al., 1994)

rux⁹ has phenotype, suppressible by CycB^unspecified

(Gonczy et al., 1994)

NOT suppressed by

Statement

Reference

rux⁹ has phenotype, non-suppressible by stg⁴

(Gonczy et al., 1994)

rux⁹ has phenotype, non-suppressible by Cdk1^unspecified

(Gonczy et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Lowering the dose of CycA or twe rescues the rux germline phenotype. Lowering the dose of CycB only partially rescues the rux germline phenotype. Lowering the dose of stg or cdc2 has no effect on the germline phenotype of rux.

(Gonczy et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mobilization of the P-element can generate revertants that have lost the male sterility.

(Gonczy et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

rux⁹

(Franklin-Dumont et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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