FB2024_03 , released June 25, 2024
Allele: Dmel\repo1
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General Information
Symbol
Dmel\repo1
Species
D. melanogaster
Name
FlyBase ID
FBal0035504
Feature type
allele
Associated gene
Dmel\repo
Associated Insertion(s)
P{Cg1-3'dup.CAT+}repo1
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Xiong et al., 1994)
Mutagen
P-element activity
(Xiong et al., 1994)
Progenitor genotype
Associated Insertion(s)
P{Cg1-3'dup.CAT+}repo1
Cytology
Description

P-element insertion, in the opposite direction to repo transcription, into the 5' untranslated region.

(Xiong et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      repo1 mutants do not exhibit any changes in neuromuscular junction size or in the number of synaptic boutons at the third instar larval stage.

      repo1/repo03702 mutants exhibit an increase in mEJP synaptic potential amplitude, compared to wild-type.

      (Kerr et al., 2014)

      20% of animals show a retinal axon projection pattern similar to that of argos mutants. The morphology of the lamina neuropil is normal. Fasciculation of retinal axons in the optic stalk was disordered in ~10% of repo1 mutants examined.

      (Sawamoto et al., 1996)

      Homozygotes exhibit an age-dependent reverse polarity ERG recording. The lamina layer exhibits abnormalities and neural degeneration (lamina neurons and glia exhibit features of apoptosis) that becomes more pronounced in older flies. Retinal degeneration proceeds laminar cell death.

      (Xiong and Montell, 1995)

      Homozygous viable. repo ERG phenotype, ERG has a reversed polarity attributable to a cell type other than photoreceptor cells. Heterozygotes with repo03702 are semi-lethal, heterozygotes with repo00692, repo02138 and Df(3R)P14 are lethal.

      (Xiong et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      M.C. Mullins.

      (Xiong et al., 1994)
      Comments
      Comments

      Precise excision of the P-element causes reversion of the mutant phenotype to wild type.

      (Xiong et al., 1994)

      Mutant ERG phenotype closely resembles that of hrp1.

      (Petersen and Shieh, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (10)