FB2024_03 , released June 25, 2024
Allele: Dmel\y+ns
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General Information
Symbol
Dmel\y+ns
Species
D. melanogaster
Name
FlyBase ID
FBal0033195
Feature type
allele
Associated gene
Dmel\y
Associated Insertion(s)
gypsy{}y-2
P{}y+ns-a
P{}y+ns-b
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Georgiev et al., 1997, Georgiev et al., 1992)
Progenitor genotype
y2
(Georgiev et al., 1997)
Associated Insertion(s)
gypsy{}y-2
P{}y+ns-a
P{}y+ns-b
Cytology
Description

Contains a gypsy element at -700bp and a chimeric element at -69bp relative to the transcription start site. In the chimeric element, a 19.7kb sequence combined from three different X-chromosomal regions is flanked by two identical copies of a defective 1.2kb P-element which are oriented in the same way.

(Golovnin et al., 1999)

Insertion of a chimeric sequence flanked by deleted P-elements into the regulatory region of y.

(Gracheva et al., 1998)

22.1kb insertion 69bp upstream of the y transcription start site. y sequences from -146bp to -70bp are also deleted. The insertion contains a central region of 19.7kb genomic DNA flanked by two identical copies of a 1.2kb deleted P-element (nucleotides 830 to 2430 have been deleted and are replaced by a 10bp sequence), which are arranged in the same orientation. The direction of transcription of the P-elements is opposite to that of the y gene. Neither the whole insertion nor the individual P-elements are flanked by the characteristic base pair duplications that are normally found after P-element insertion. The 19.7kb genomic fragment that is flanked by the P-elements includes sequences from two, or possibly three, different regions of the X chromosome and some repetitive sequences. The gypsy element present in the progenitor y2 allele is still present.

(Georgiev et al., 1997)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      macrochaeta & adult thorax

      (Georgiev et al., 1997)

      macrochaeta & leg

      (Georgiev et al., 1997)
      Detailed Description
      Statement
      Reference

      Body colour: flies have wild-type pigmentation of the body and wings.

      (Golovnin et al., 1999)

      Body colour: body and wing wild-type; leg and thorax bristles reduced pigmentation.

      (Georgiev et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      y+ns has abnormal body color | recessive phenotype, enhanceable by su(Hw)2

      (Georgiev et al., 1997)

      y+ns has abnormal body color | recessive phenotype, enhanceable by mod(mdg4)ul

      (Georgiev et al., 1997)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      y+ns has adult cuticle & wing phenotype, enhanceable by su(Hw)2

      (Georgiev et al., 1997)

      y+ns has adult cuticle & wing phenotype, enhanceable by mod(mdg4)ul

      (Georgiev et al., 1997)

      y+ns has macrochaeta & leg phenotype, enhanceable by mod(mdg4)ul

      (Georgiev et al., 1997)

      y+ns has wing sensillum phenotype, enhanceable by mod(mdg4)ul

      (Georgiev et al., 1997)

      y+ns has macrochaeta & adult abdomen phenotype, enhanceable by mod(mdg4)ul

      (Georgiev et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      su(Hw)2 reduces body and wing pigmentation in y+ns males, but does not affect bristle pigmentation; mod(mdg4)ul partially decreases pigmentation of all cuticular structures in y+ns males.

      (Georgiev et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Very unstable allele.

      (Georgiev et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      y+ns
      Name Synonyms
      Secondary FlyBase IDs
        References (6)