FB2024_03 , released June 25, 2024
Allele: Dmel\wblM46
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General Information
Symbol
Dmel\wblM46
Species
D. melanogaster
Name
FlyBase ID
FBal0033170
Feature type
allele
Associated gene
Dmel\wbl
Associated Insertion(s)
Carried in Construct
Also Known As
windM46
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Konsolaki and Schupbach, 1998)
Progenitor genotype
Cytology
Description

Single base change, resulting in the generation of a stop codon (UAG) after amino acid 187.

(Konsolaki and Schupbach, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,250,590..19,250,590 [+]
Nucleotide change:

C19250590T

Amino acid change:

Q188term | wbl-PA; Q188term | wbl-PB

Reported amino acid change:

Q188term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Konsolaki and Schupbach, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from homozygous females are strongly dorsalised. Homozygous adults show reduced viability. Transheterozygotes with wblRP, wblM88, wblT6, wblE4 or wblAR51 also have reduced viability, and embryos derived from these transheterozygous females are dorsalised and fail to hatch.

      (Konsolaki and Schupbach, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant combinations with eaD3 are strongly dorsalized.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wblM46
      windM46
      (Han et al., 2000, LeMosy et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)