FB2024_03 , released June 25, 2024
Allele: Dmel\tldB4
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General Information
Symbol
Dmel\tldB4
Species
D. melanogaster
Name
FlyBase ID
FBal0032867
Feature type
allele
Associated gene
Dmel\tld
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Raftery et al., 1995, Childs and O'Connor, 1994, Arora and Nusslein-Volhard, 1992, Ferguson and Anderson, 1992, Shimell et al., 1991)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C130T.

    (Childs and O'Connor, 1994)

    Amino acid replacement: Q44term.

    (Childs and O'Connor, 1994)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:24,749,955..24,749,955 [+]
    Nucleotide change:

    C24749955T

    Reported nucleotide change:

    C130T

    Amino acid change:

    Q54term | tld-PA

    Reported amino acid change:

    Q44term

    Comment:

    Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported nucleotide substitution due to different start site used by authors.

    (Childs and O'Connor, 1994)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        No significant enhancement of the dpp mutant phenotype.

        (Raftery et al., 1995)

        Moderate ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

        (Arora and Nusslein-Volhard, 1992)

        Embryos are ventralised.

        (Ferguson and Anderson, 1992)

        Lack all of the dorsally derived cuticular specializations of the head and the prominent dorsolaterally derived structure of the tail, the filzkorper.

        (Shimell et al., 1991)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Mutant phenotype can be suppressed by doubling the dose of dpp+.

        (Ferguson and Anderson, 1992)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Strong tld allele.

        (Childs and O'Connor, 1994)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        References (16)