FB2024_03 , released June 25, 2024
Allele: Dmel\sggA.hs
Open Close
General Information
Symbol
Dmel\sggA.hs
Species
D. melanogaster
Name
FlyBase ID
FBal0032710
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{hs-sgg.A}
Key Links
Transgenic product class
cDNA
(Siegfried et al., 1992)
wild_type
(Siegfried et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Siegfried et al., 1992)
wild_type
(Siegfried et al., 1992)
Mutagen
in vitro construct
(Siegfried et al., 1992)
Progenitor genotype
Carried in construct
P{hs-sgg.A}
Cytology
Description

A cDNA encoding the A variant of the sgg product is driven by a heat inducible promoter.

(Siegfried et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
sgg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing sggA.hs have a wild-type tissue polarity phenotype in the wing.

      (Axelrod et al., 1998)

      Different classes of heart phenotype are produced when embryos carrying sggA.hs are heat shocked for 40 minutes during 3.5 to 4.5 hours of development; 15% of embryos show an increase in heart formation, and 14% of embryos show a decrease in heart formation.

      (Park et al., 1998)

      Heat shock for 30 minutes at 3.5 hours of development has no effect on heart precursor formation.

      (Park et al., 1996)

      Expression of the sgg-A protein is sufficient to rescue all aspects of the sgg mutant phenotype.

      (Siegfried et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      sggA.hs is a suppressor of phenotype of wgsev.PC

      (Cadigan and Nusse, 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Overexpression of sgg can suppress the P{sev-wg.C} phenotype, almost complete loss of interommatidial bristles.

      (Cadigan and Nusse, 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      sggA.hs rescues sgg1

      (Wojcik, 2008)

      sggA.hs rescues sggM11

      (Siegfried et al., 1992)
      Comments

      Expression of sggA.hs rescues the curved spindle phenotype seen in the neuroblasts of hemizygous and homozygous sgg1 mutant larvae.

      (Wojcik, 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sggA.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (6)