FB2024_03 , released June 25, 2024
Allele: Dmel\rutMB2769
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General Information
Symbol
Dmel\rutMB2769
Species
D. melanogaster
Name
FlyBase ID
FBal0032630
Feature type
allele
Associated gene
Dmel\rut
Associated Insertion(s)
P{lArB}rutMB2769
Carried in Construct
Also Known As
P{lArB}rutMB2769
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Han et al., 1996, Han et al., 1992)
Progenitor genotype
P{lArB}A4.1M2
(Han et al., 1996)
Associated Insertion(s)
P{lArB}rutMB2769
Cytology
Description

P{lArB} insertion within 200bp upstream of the presumed transcription start site.

(Han et al., 1996)

P{lArB} insertion at -168bp, in same orientation as rut transcription.

(Han et al., 1992)
Allele components
Component
Use(s)
Inserted element
P{lArB}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      rutMB2769 mutants show impaired performance in tests of 3 minute memory after classical conditioning for odors, although this impairment is not a severe as that seen in rut2080 mutants.

      (Mao et al., 2004)

      Severe defects in initial learning and in 60 minute memory retention, measured in negatively reinforced olfactory discrimination paradigm.

      (Han et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      rut1

      (Han et al., 1992)
      Rescued by

      rutMB2769 is rescued by Scer\GAL4Mef2.247.Switch/rutUAS.cZa

      (Mao et al., 2004)
      Comments

      The short term memory deficit of rutMB2769 mutants is completely rescued by rutScer\UAS.cZa; Scer\GAL4Mef2.247.Switch after feeding with 500μM RU486 for 2 days.

      (Mao et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rut2769
      (Mao et al., 2004)
      rutMB2769
      Name Synonyms
      Secondary FlyBase IDs
        References (3)