FlyBase Allele Report: Dmel\ptc[G12]

General Information

Symbol

Dmel\ptc^G12

Species

D. melanogaster

Name

FlyBase ID

FBal0032506

Feature type

allele

Associated gene

Dmel\ptc

Associated Insertion(s)

Carried in Construct

Also Known As

Df(2R)ptc^G12

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Ingham and Hidalgo, 1993)

Mutagen

gamma ray

(Phillips et al., 1990)

Progenitor genotype

Cytology

Description

Deletion of the coding region.

(Ingham and Hidalgo, 1993)

Deficiency of the entire ptc gene.

(Ingham et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage (with ptc^tuf-1)

(Thomas and Ingham, 2003)

lethal - all die during embryonic stage

(Phillips et al., 1990)

some die during embryonic stage

(Phillips et al., 1990)

Phenotype Manifest In

adult head bristle (with ptc^tuf-1)

(Thomas and Ingham, 2003)

adult head bristle | ectopic (with ptc^tuf-1)

(Thomas and Ingham, 2003)

antenna (with ptc^tuf-1)

(Thomas and Ingham, 2003)

eye (with ptc^tuf-1)

(Thomas and Ingham, 2003)

frons (with ptc^tuf-1)

(Thomas and Ingham, 2003)

fronto-orbital plate (with ptc^tuf-1)

(Thomas and Ingham, 2003)

head capsule & cuticle | ectopic (with ptc^tuf-1)

(Thomas and Ingham, 2003)

Keilin organ

(Simcox et al., 1989)

ocellar triangle (with ptc^tuf-1)

(Thomas and Ingham, 2003)

ommatidium (with ptc^tuf-1)

(Thomas and Ingham, 2003)

ventral denticle belt

(Quirk et al., 1997)

Detailed Description

Statement

Reference

ptc^G12/ptc^tuf-1 flies have severely reduced, rough eyes, and a mildly enlarged head vertex (ocellar triangle, fronto-orbital plate and frons). They occasionally lack one or both antennae.

(Thomas and Ingham, 2003)

Homozygotes exhibit reduced number of denticle rows and each belt is rectangular shape.

(Quirk et al., 1997)

Nondefective in gonad assembly.

(Warrior, 1994)

Double mutant embryos with hh²¹ are larger than hh²¹ homozygotes and exhibit a phenotype similar to ptc.

(Ingham et al., 1991)

ptc mutant embryos have Keilin's organs, but these often have four or more sensory hairs rather than the normal three. ptc^G12/ptc^S2 and ptc^G12/ptc⁹ embryos grew in in vivo culture, producing implants containing larval gut, Malpighian tubule, fat body, salivary gland, brain and imaginal discs. The discs tended to grow as a mass of merged sheet of material. Metamorphosed implants produced adult cuticular structures derived from the eye-antenna, leg and wing discs.

(Simcox et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ptc[+]/ptc^G12 is a suppressor of visible phenotype of Scer\GAL4^C-765, smo^{5A.UAS.Tag:FLAG}

(Collins and Cohen, 2005)

ptc[+]/ptc^G12 is a suppressor of visible phenotype of CycE^JP

(Brumby et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

ptc^G12 has ventral denticle belt phenotype, suppressible by smo³

(Quirk et al., 1997)

Suppressor of

Statement

Reference

ptc[+]/ptc^G12 is a suppressor of 1st posterior cell phenotype of Scer\GAL4^C-765, smo^{5A.UAS.Tag:FLAG}

(Collins and Cohen, 2005)

ptc[+]/ptc^G12 is a suppressor of wing vein L3 phenotype of Scer\GAL4^C-765, smo^{5A.UAS.Tag:FLAG}

(Collins and Cohen, 2005)

ptc[+]/ptc^G12 is a suppressor of wing vein L4 phenotype of Scer\GAL4^C-765, smo^{5A.UAS.Tag:FLAG}

(Collins and Cohen, 2005)

ptc[+]/ptc^G12 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2004)

Other

Statement

Reference

Scer\GAL4^e22c, hh^UAS.cIa, ptc^G12 has ventral denticle belt phenotype

(Quirk et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction in distance between wing veins III and IV and partial fusions of these veins proximal to the anterior crossvein that is seen in flies expressing smo^{5A.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^C-765 are suppressed by ptc^G12/+; the resulting flies have nearly normal wings.

(Collins and Cohen, 2005)

Has no effect on the eye phenotype produced by activated arm constructs. (either arm^S44Y.GMR or arm^S56F.GMR).

(Freeman and Bienz, 2001)

ptc^G12 smo³ double homozygotes raised at 25^oC show an essentially wild type phenotype. Scer\GAL4^e22c-mediated expression of hh^Scer\UAS.cIa changes the denticle belt morphology.

(Quirk et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ptc^G12 is rescued by ptc^hs.PI

(Ingham et al., 1991)

Comments

Mutant phenotype can be completely or partially rescued by ptc^hs.PI.

(Ingham et al., 1991)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Df(2R)ptc^G12

(Thomas and Ingham, 2003, Taylor et al., 1993, Ingham et al., 1991)

ptc^G12

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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